Effects of limonene and essential oil from Citrus aurantium on gastric mucosa: Role of prostaglandins and gastric mucus secretion

Essential oil from Citrus aurantium and the monoterpene limonene are widely used flavoring agents that are found in some common food items. This specie is also used medicinally throughout the world to treat gastritis and gastric disorders. Therefore, biological assays were performed in vivo on essen...

Full description

Saved in:
Bibliographic Details
Published in:Chemico-biological interactions 2009-08, Vol.180 (3), p.499-505
Main Authors: Moraes, Thiago M., Kushima, Hélio, Moleiro, Fábio C., Santos, Raquel C., Machado Rocha, Lúcia R., Marques, Márcia O., Vilegas, Wagner, Hiruma-Lima, Clélia A.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Citrus - chemistry
Citrus aurantium
Cyclohexenes - administration & dosage
Cyclohexenes - pharmacology
Drug abuse
Essential oil
Ethanol - administration & dosage
Gastric Mucosa - drug effects
Gastric Mucosa - secretion
Gastric protection
Limonene
Male
Mucus - secretion
Oils, Volatile - administration & dosage
Oils, Volatile - pharmacology
PGE 2
Prostaglandins - physiology
Prostaglandins - secretion
Rats
Rats, Wistar
Stomach Ulcer - chemically induced
Stomach Ulcer - drug therapy
Terpenes - administration & dosage
Terpenes - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Essential oil from Citrus aurantium and the monoterpene limonene are widely used flavoring agents that are found in some common food items. This specie is also used medicinally throughout the world to treat gastritis and gastric disorders. Therefore, biological assays were performed in vivo on essential oil of C. aurantium (OEC) and its majority compound limonene (LIM) to evaluate their effect on gastric mucosa. The OEC (250 mg/kg, p.o.) and LIM (245 mg/kg, p.o.) provided effective (99%) gastroprotection against lesions induced by absolute ethanol and NSAID (non-steroidal anti-inflammatory drug) in rats. OEC and LIM do not interfere with gastric H + secretion, serum gastrin or glutathione (GSH) level in gastric mucosa. But the gastroprotective action of OEC and LIM occurs due to an increase in the gastric mucus production induced by conserving the basal PGE 2 levels after challenge by agents harmful to the gastric mucosa. Given that LIM and OEC are excellent flavoring agents and also present gastroprotective actions, they can be regarded as a promising target for the development of a new drug for the prevention of gastric damage.
ISSN:0009-2797
1872-7786
DOI:10.1016/j.cbi.2009.04.006