Excessive daytime sleepiness may be associated with caudate denervation in Parkinson disease

Excessive daytime sleepiness (EDS) is one of the earliest and most common non-motor symptoms of PD, substantially impacting on patient's quality of life. Using the Parkinson's Progression Markers Initiative database, we performed a case-control study to investigate whether dopaminergic def...

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Bibliographic Details
Published in:Journal of the neurological sciences 2018-04, Vol.387, p.220-227
Main Authors: Yousaf, Tayyabah, Pagano, Gennaro, Niccolini, Flavia, Politis, Marios
Format: Article
Language:English
Subjects:
[123I]FP-CIT
Aged
Caudate
Caudate Nucleus - diagnostic imaging
Caudate Nucleus - drug effects
Disorders of Excessive Somnolence - diagnostic imaging
Disorders of Excessive Somnolence - etiology
Dopamine Agonists - therapeutic use
Dopamine Plasma Membrane Transport Proteins - drug effects
Dopamine Plasma Membrane Transport Proteins - metabolism
Excessive daytime sleepiness
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Parkinson
Parkinson Disease - complications
Parkinson Disease - diagnostic imaging
Parkinson Disease - drug therapy
Protein Binding - drug effects
Severity of Illness Index
Statistics, Nonparametric
Tomography, Emission-Computed, Single-Photon
Tropanes - pharmacokinetics
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Summary:Excessive daytime sleepiness (EDS) is one of the earliest and most common non-motor symptoms of PD, substantially impacting on patient's quality of life. Using the Parkinson's Progression Markers Initiative database, we performed a case-control study to investigate whether dopaminergic deficit is associated with the development of EDS using dopaminergic specific single photon emission computed tomography (SPECT) molecular imaging of dopamine transporters (DAT). We enrolled 84 early de novo PD patients with EDS and 84 without EDS, who were matched for age, gender, age of diagnosis, years of education and disease duration. We assessed and compared semi-quantified [123I]FP-CIT SPECT, and motor and non-motor features among these two groups, alongside exploring the clinical and imaging correlates of EDS and the predictive significance of these markers in the development of EDS. PD patients with EDS had worse non-motor (MDS-UPDRS Part-I, P 
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2018.02.032