Effects of oxidative stress induced by high dosage of dietary iron ingested on intestinal damage and caecal microbiota in Chinese Yellow broilers

Summary The objective of this trial was to test the effects of oxidative stress induced by a high dosage of dietary iron on intestinal lesion and the microbiological compositions in caecum in Chinese Yellow broilers. A total of 450 1‐day‐old male chicks were randomly allotted into three groups. Supp...

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Bibliographic Details
Published in:Journal of animal physiology and animal nutrition 2018-08, Vol.102 (4), p.924-932
Main Authors: Gou, Z. Y., Li, L., Fan, Q. L., Lin, X. J., Jiang, Z. Y., Zheng, C. T., Ding, F. Y., Jiang, S. Q.
Format: Article
Language:English
Subjects:
Animal Feed
Animals
Autophagy
Birds
caecal microbiota
Cecum - microbiology
Cecum - pathology
Chickens
Chicks
Chinese Yellow broiler
Composition
Copper
Diet
Diet - veterinary
Dietary Supplements
Dosage
Electrophoresis
Endoplasmic reticulum
Enterocytes
Flora
Gastrointestinal Tract - drug effects
Gastrointestinal Tract - pathology
Gel electrophoresis
Gene expression
Glutathione
intestinal lesion
Intestine
Iron
Iron, Dietary - administration & dosage
Iron, Dietary - adverse effects
Jejunum
Juveniles
Male
Malondialdehyde
Microbiota
Microorganisms
Mucosa
Oxidative stress
Oxidative Stress - drug effects
Superoxide dismutase
Transmission electron microscopy
Ultrastructure
Zinc
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Summary:Summary The objective of this trial was to test the effects of oxidative stress induced by a high dosage of dietary iron on intestinal lesion and the microbiological compositions in caecum in Chinese Yellow broilers. A total of 450 1‐day‐old male chicks were randomly allotted into three groups. Supplemental iron (0, 700 and 1,400 mg/kg) was added to the basal diet resulting in three treatments containing 245, 908 and 1,651 mg/kg Fe (measured value) in diet respectively. Each treatment consisted of six replicate pens with 25 birds per pen. Jejunal enterocyte ultrastructure was observed by transmission electron microscopy. The results showed that a high dosage of dietary iron induced oxidative stress in broilers. Dilated endoplasmic reticulum (ER), autophagosome formation of jejunal enterocytes and decreased villi were caused by this oxidative stress. Compared to the control, concentration of the malondialdehyde (MDA) in jejunal mucosa in the 908 and 1,651 mg/kg Fe groups increased by 180% (p 
ISSN:0931-2439
1439-0396
DOI:10.1111/jpn.12885