Insect growth regulatory activity of carvacrol-based 1,3,4-thiadiazoles and 1,3,4-oxadiazoles

  In designing of novel insect growth regulators (IGRs), biologically occurring carvacrol has been structurally modified to thiadiazole and oxadiazole moieties. Two series of carvacrol analogs containing 1,3,4-thiadiazole (VIIIa–e) and 1,3,4-oxadiazole (IXa–e) derivatives are designed and synthesize...

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Bibliographic Details
Published in:Molecular diversity 2018-08, Vol.22 (3), p.647-655
Main Authors: Bagul, Suresh D., Rajput, Jamatsing D., Srivastava, Chitra, Bendre, Ratnamala S.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Growth regulators
Life Sciences
Organic Chemistry
Original Article
Pharmacy
Polymer Sciences
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Summary:  In designing of novel insect growth regulators (IGRs), biologically occurring carvacrol has been structurally modified to thiadiazole and oxadiazole moieties. Two series of carvacrol analogs containing 1,3,4-thiadiazole (VIIIa–e) and 1,3,4-oxadiazole (IXa–e) derivatives are designed and synthesized. Their structures are confirmed by FT-IR, 1 H NMR, 13 C NMR and LC-MS. IGR activity is tested against Spodoptera litura. Several analogs displayed IGR activity against this insect pest. Compounds VIIIe and IXe displayed relatively good IGR activity with GI 50 values 117.43 and 108.83 ppm against Spodoptera litura , respectively. Graphical Abstract Synthesis, characterization and evaluation of carvacrol-based 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives as potent insect growth regulators (IGRs).
ISSN:1381-1991
1573-501X
DOI:10.1007/s11030-018-9823-6