1-Benzyl-1,2,3,4-Tetrahydroisoquinoline, an Endogenous Parkinsonism-Inducing Toxin, Strongly Potentiates MAO-Dependent Dopamine Oxidation and Impairs Dopamine Release: Ex vivo and In vivo Neurochemical Studies

1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), an endogenous neurotoxin, is known to cause a parkinsonism-like syndrome in rodents and primates. In this study we evaluated the effects of single and multiple 1BnTIQ (50 mg/kg i.p.) administration on the concentrations of dopamine, serotonin, and re...

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Bibliographic Details
Published in:Neurotoxicity research 2009, Vol.15 (1), p.15-23
Main Authors: Wąsik, Agnieszka, Romańska, Irena, Antkiewicz-Michaluk, Lucyna
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Basal Ganglia - chemistry
Basal Ganglia - drug effects
Biomedical and Life Sciences
Biomedicine
Brain Chemistry - drug effects
Cell Biology
Dopamine - metabolism
Drug Administration Schedule
Male
Microdialysis - methods
Motor Activity - drug effects
Muscle Rigidity - chemically induced
Neurobiology
Neurochemistry
Neurology
Neurosciences
Neurotoxins - pharmacology
Pharmacology/Toxicology
Primates
Rats
Rats, Wistar
Tetrahydroisoquinolines - chemistry
Tetrahydroisoquinolines - pharmacology
Time Factors
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Summary:1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), an endogenous neurotoxin, is known to cause a parkinsonism-like syndrome in rodents and primates. In this study we evaluated the effects of single and multiple 1BnTIQ (50 mg/kg i.p.) administration on the concentrations of dopamine, serotonin, and respective metabolites (homovanillic acid, HVA; 3,4-dihydroxyphenylacetic acid, DOPAC; 3-methoxytyramine, 3-MT; and 5-hydroxyindolacetic acid, 5-HIAA), in substantia nigra, striatum (STR), and nucleus accumbens of Wistar rats. In addition, the effect of 1BnTIQ on locomotor activity and dopamine release in vivo was also estimated in rat STR. In a behavioral study, acute administration of 1BnTIQ (50 mg/kg i.p.) produced a significant decrease in exploratory locomotor activity. A high-performance liquid chromatography with electrochemical detection ex vivo study showed that a single injection of 1BnTIQ produced a dramatic fall in the dopamine concentration in the noted brain regions (~65%; P  
ISSN:1029-8428
1476-3524
DOI:10.1007/s12640-009-9001-9