Synthesis and biological activity of 5-aryl-4-acyl-3-hydroxy-1-morpholinoalkyl-3-pyrrolin-2-ones

A series of 5-aryl-4-acyl-3-hydroxy-1-morpholinoalkyl-3-pyrroline-2-ones was synthesized via the reactions of methyl esters of acylpyruvic acids with a mixture of aromatic aldehyde and 2-(4-morpholino)-1-ethylamine or 3-(4-morpholino)-1-propylamine. All compounds possess weak antibacterial propertie...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2007-05, Vol.41 (5), p.256-263
Main Authors: Gein, V. L., Yushkov, V. V., Kasimova, N. N., Voronina, E. V., Rakshina, N. S., Vasil’eva, M. Yu
Format: Article
Language:English
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Summary:A series of 5-aryl-4-acyl-3-hydroxy-1-morpholinoalkyl-3-pyrroline-2-ones was synthesized via the reactions of methyl esters of acylpyruvic acids with a mixture of aromatic aldehyde and 2-(4-morpholino)-1-ethylamine or 3-(4-morpholino)-1-propylamine. All compounds possess weak antibacterial properties. The antiamnesic, analgesic, and antiphlogistic activity and acute toxicity of several compounds were studied. It was established that one compound produced a significant antiamnesic effect and two compounds exhibited pronounced analgesic activity.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-007-0057-7