A graphical method for comparing nocturnal oxygen saturation profiles in individuals and populations: Application to healthy infants and preterm neonates

Study Objectives Pulse‐oximetry (SpO2) allows the identification of important clinical physiology. However, summary statistics such as mean values and desaturation incidence do not capture the complexity of the information contained within continuous recordings. The aim of this study was to develop...

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Bibliographic Details
Published in:Pediatric pulmonology 2018-05, Vol.53 (5), p.645-655
Main Authors: Terrill, Philip I., Dakin, Carolyn, Edwards, Bradley A., Wilson, Stephen J., MacLean, Joanna E.
Format: Article
Language:English
Subjects:
apnoea of prematurity
Baby foods
infant sleep and breathing
intermittent hypoxemia
Newborn babies
oxygen desaturations
Premature birth
pulse oximetry
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Summary:Study Objectives Pulse‐oximetry (SpO2) allows the identification of important clinical physiology. However, summary statistics such as mean values and desaturation incidence do not capture the complexity of the information contained within continuous recordings. The aim of this study was to develop an objective method to quantify important SpO2 characteristics; and assess its utility in healthy infant and preterm neonate cohorts. Methods An algorithm was developed to calculate the desaturation incidence, depth, and duration. These variables are presented using three plots: SpO2 cumulative‐frequency relationship; desaturation‐depth versus incidence; desaturation‐duration versus incidence. This method was applied to two populations who underwent nocturnal pulse‐oximetry: (1) thirty‐four healthy term infants studied at 2‐weeks, 3, 6, 12, and 24‐months of age and (2) thirty‐seven neonates born
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.23987