Relationship of hematologic markers with IL-17 and IL-1 beta in patients with rheumatoid arthritis

• Published in: Journal of back and musculoskeletal rehabilitation 2018-01, Vol.31 (4), p.703-707
• Main Authors: Sağ, S, Sağ, M S, Tekeoğlu, I, Kamanlı, A, Nas, K, Acar, B A
• Format: Article
• Language: English
• Subjects: Age; Arthritis, Rheumatoid - blood; Biomarkers - blood; Blood platelets; Blood tests; Body mass index; C-reactive protein; C-Reactive Protein - analysis; Case-Control Studies; Cell Count; Cytokines; ErbB-2 protein; Erythrocyte sedimentation rate; Female; Humans; Interleukin 1; Interleukin 17; Interleukin-17 - blood; Interleukin-1beta - blood; Lymphocytes; Lymphocytes - metabolism; Male; Mean Platelet Volume; Middle Aged; Neutrophils; Neutrophils - metabolism; Platelets; Rheumatoid arthritis; Smoking; Statistical analysis
• ISSN: 1053-8127; 1878-6324
• DOI: 10.3233/BMR-170903

In this study, we aimed to investigate the relationship of NLR (Neutrophil lymphocyte ratio), MPV (mean platelet volume), PDW (distribution width) rates in rheumatoid arthritis (RA) patients with IL-17 and IL-1 beta which are within the cytokines playing an important role in etiopathogenesis and activity of the disease. Fifty-seven RA patients diagnosed according to RA classification criteria of ACR/EULAR 2010 and 37 controls were included into the study. WBC (white blood cell), NEU (neutrophil), PLT (platelet), LYM (lymphocyte) values in complete blood count received from routine blood examination of patients were recorded, and NLR, PLR (platelet lymphocyte ratio) rates were recorded. IL-17 and IL-1 beta were studies in serum samples. Disease activity of RA patients was evaluated with Disease Activity Score (DAS28). Age, gender, disease age, BMI (body mass index), medications used, co-morbid diseases, smoking of the patients were recorded. Fifty-seven RA patients (46 (80.7%) females, 11 (19.3%) males), and 34 patients (24 (70.6% females and 10 (29.4) males) as a control group were involved. Demographic characteristics were similar between two groups, and statistically significant difference was not detected between patient and control groups in terms of gender, age, and BMI (p> 0.05). We found higher NLR, MPV, PDW, IL-17 values in RA patients compared to control group (p< 0.05). There was a positive correlation of NLR with DAS28, CRP. While erythrocyte sedimentation rate (ESR) had negative correlation with MPV and PDW, it had positive correlation with PLT. We found positive correlation of C-reactive protein (CRP) with NLR and PLT. We could not find correlation of IL-1 beta and IL-17 with hematologic markers. In this study, we investigated the relationship of IL-17 and IL-1 beta which play an important role in pathogenesis of RA patients with the parameters analyzed in routine complete blood count, providing information about disease activity such as DAS 28, CRP, and ESR. We illuminated on an issue which has not discussed before by looking from a different angle. More extensive, follow-up studies are needed to emphasize the importance of these parameters and to reveal the relationship between cytokines during the follow-up of the disease activity.