miR-146a rs2910164 polymorphism and the risk of colorectal cancer in Chinese population

Objective: MicroRNAs-associated single nucleotide polymorphisms are thought to play an important role in cancer development. We investigated the association of miR-146a rs2910164 polymorphism with the risk of colorectal cancer (CRC) in Chinese population. Materials and Methods: In this hospital-base...

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Bibliographic Details
Published in:Journal of cancer research and therapeutics 2018-01, Vol.14 (8), p.97-99
Main Authors: Gao, Xueren, Zhu, Zhansheng, Zhang, Shulong
Format: Article
Language:English
Subjects:
Age
Aged
Alleles
Asians - genetics
Bladder cancer
Case-Control Studies
China - epidemiology
Colorectal cancer
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - genetics
Deoxyribonucleic acid
DNA
Female
Gastric cancer
Gender
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Health risk assessment
Humans
Liver cancer
Lung cancer
Male
Medical prognosis
MicroRNAs
MicroRNAs - genetics
Middle Aged
Pathogenesis
Polymorphism
Polymorphism, Single Nucleotide
Population
Population Surveillance
Risk Assessment
Risk Factors
Studies
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Summary:Objective: MicroRNAs-associated single nucleotide polymorphisms are thought to play an important role in cancer development. We investigated the association of miR-146a rs2910164 polymorphism with the risk of colorectal cancer (CRC) in Chinese population. Materials and Methods: In this hospital-based case-control study of 560 cases and 780 age- and gender-matched healthy controls, the miR-146a rs2910164 polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism. Results: We found that miR-146a rs2910164 polymorphism was not associated with CRC risk. However, the subgroup analysis by gender showed significant associations in male subjects (GG vs. CC: Odds ratios [OR] = 1.54, 95% confidence intervals [CI] = 1.04-2.29, P = 0.03; G vs. C: OR = 1.21, 95% CI = 1.01-1.45, P = 0.04). Conclusion: Our study provides evidence that miR-146a rs2910164 polymorphism may play an important role in susceptibility to CRC in Chinese male population.
ISSN:0973-1482
1998-4138
DOI:10.4103/0973-1482.165864