Beta 2-Microglobulin and the Severity of Coronary Stenosis in Patients With Acute Coronary Syndrome

Previous studies have shown that beta 2-microglobulin (B2M) could predict all-cause mortality and cardiovascular mortality in various groups of people. However, the relationship between B2M and severity of coronary stenosis in patients with acute coronary syndrome has not been established. We enroll...

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Bibliographic Details
Published in:Heart, lung & circulation lung & circulation, 2019-04, Vol.28 (4), p.575-582
Main Authors: Zhang, Chenglong, Li, Fengjuan, Long, Tianyi, Li, Fei, Peng, Liming, Xia, Ke, Jing, Ran, Xie, Qiying, Yang, Tianlun
Format: Article
Language:English
Subjects:
Acute coronary syndrome
Acute Coronary Syndrome - complications
Acute Coronary Syndrome - diagnosis
Acute Coronary Syndrome - epidemiology
Beta 2-microglobulin
beta 2-Microglobulin - blood
Biomarkers - blood
Cause of Death - trends
China - epidemiology
Coronary angiography
Coronary Angiography - methods
Coronary Stenosis - blood
Coronary Stenosis - complications
Coronary Stenosis - diagnosis
Female
Follow-Up Studies
Gensini score
Humans
Male
Middle Aged
Prevalence
Retrospective Studies
Risk Factors
Severity of Illness Index
Survival Rate - trends
Triple-vessel disease
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Summary:Previous studies have shown that beta 2-microglobulin (B2M) could predict all-cause mortality and cardiovascular mortality in various groups of people. However, the relationship between B2M and severity of coronary stenosis in patients with acute coronary syndrome has not been established. We enrolled 872 consecutive patients admitted with acute coronary syndrome in our study. All participants underwent coronary angiography examination or stent implantation after admission. The severity of coronary stenosis was assessed by Gensini score and the presentation of triple-vessel disease. B2M and other biochemical parameters were measured. All subjects were divided into quartiles of B2M. Multivariate linear regression and logistic regression were applied in the analysis. Gensini score and the prevalence of triple-vessel disease were elevated in accordance with increasing B2M quartiles (p=0.002 and p0.05 for both). Our data indicated that B2M was an independent risk factor of coronary stenosis in patients with acute coronary syndrome.
ISSN:1443-9506
1444-2892
DOI:10.1016/j.hlc.2018.02.016