Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area

To assess the possible function of glutamate in the interaction between the dorsomedial hypothalamic nucleus-perifornical area (DMH-PeF) and the A5 pontine region (A5), cardiovascular and respiratory changes were studied in response to electrical stimulation of the DMH-PeF (1 ms pulses, 30–50 μA giv...

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Bibliographic Details
Published in:Journal of physiology and biochemistry 2018-05, Vol.74 (2), p.325-334
Main Authors: López-González, M. V., Díaz-Casares, A., González-García, M., Peinado-Aragonés, C. A., Barbancho, M. A., Carrillo de Albornoz, M., Dawid-Milner, M. S.
Format: Article
Language:English
Subjects:
6-Cyano-7-nitroquinoxaline-2,3-dione - administration & dosage
Animal Physiology
Animals
Biomedical and Life Sciences
Biomedicine
Blood Pressure
Cardiac arrhythmia
Cardiovascular Physiological Phenomena
Cardiovascular system
Dizocilpine
Dizocilpine Maleate - administration & dosage
Dorsomedial Hypothalamic Nucleus - physiology
Electric Stimulation
Electrical stimuli
Excitatory Amino Acid Antagonists - administration & dosage
Fornix, Brain - physiology
Glutamic acid receptors (ionotropic)
Glutamic acid receptors (metabotropic)
Glycine - administration & dosage
Glycine - analogs & derivatives
Heart Rate
Human Physiology
Hypothalamus
Kynurenic acid
Kynurenic Acid - administration & dosage
Male
Microinjection
Microinjections
N-Methyl-D-aspartic acid receptors
Nuclei
Original Article
Rats
Receptors
Receptors, Glutamate - physiology
Respiration
Respiratory Rate
Stimulation
Tachycardia
Tachycardia - physiopathology
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Summary:To assess the possible function of glutamate in the interaction between the dorsomedial hypothalamic nucleus-perifornical area (DMH-PeF) and the A5 pontine region (A5), cardiovascular and respiratory changes were studied in response to electrical stimulation of the DMH-PeF (1 ms pulses, 30–50 μA given at 100 Hz for 5 s) before and after the microinjection of kynurenic acid (non-specific glutamate receptor antagonist; 50 nl, 5 nmol), MK-801 (NMDA receptor antagonist; 50 nl, 50 nmol), CNQX (non-NMDA receptor antagonist; 50 nl, 50 nmol) or MCPG (metabotropic glutamate receptor antagonist; 50 nl, 5 nmol) within the A5 region. DMH-PeF electrical stimulation elicited a pressor ( p  
ISSN:1138-7548
1877-8755
DOI:10.1007/s13105-018-0623-3