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Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area

To assess the possible function of glutamate in the interaction between the dorsomedial hypothalamic nucleus-perifornical area (DMH-PeF) and the A5 pontine region (A5), cardiovascular and respiratory changes were studied in response to electrical stimulation of the DMH-PeF (1 ms pulses, 30–50 μA giv...

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Published in:Journal of physiology and biochemistry 2018-05, Vol.74 (2), p.325-334
Main Authors: López-González, M. V., Díaz-Casares, A., González-García, M., Peinado-Aragonés, C. A., Barbancho, M. A., Carrillo de Albornoz, M., Dawid-Milner, M. S.
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creator López-González, M. V.
Díaz-Casares, A.
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Carrillo de Albornoz, M.
Dawid-Milner, M. S.
description To assess the possible function of glutamate in the interaction between the dorsomedial hypothalamic nucleus-perifornical area (DMH-PeF) and the A5 pontine region (A5), cardiovascular and respiratory changes were studied in response to electrical stimulation of the DMH-PeF (1 ms pulses, 30–50 μA given at 100 Hz for 5 s) before and after the microinjection of kynurenic acid (non-specific glutamate receptor antagonist; 50 nl, 5 nmol), MK-801 (NMDA receptor antagonist; 50 nl, 50 nmol), CNQX (non-NMDA receptor antagonist; 50 nl, 50 nmol) or MCPG (metabotropic glutamate receptor antagonist; 50 nl, 5 nmol) within the A5 region. DMH-PeF electrical stimulation elicited a pressor ( p  
doi_str_mv 10.1007/s13105-018-0623-3
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V. ; Díaz-Casares, A. ; González-García, M. ; Peinado-Aragonés, C. A. ; Barbancho, M. A. ; Carrillo de Albornoz, M. ; Dawid-Milner, M. S.</creator><creatorcontrib>López-González, M. V. ; Díaz-Casares, A. ; González-García, M. ; Peinado-Aragonés, C. A. ; Barbancho, M. A. ; Carrillo de Albornoz, M. ; Dawid-Milner, M. S.</creatorcontrib><description><![CDATA[To assess the possible function of glutamate in the interaction between the dorsomedial hypothalamic nucleus-perifornical area (DMH-PeF) and the A5 pontine region (A5), cardiovascular and respiratory changes were studied in response to electrical stimulation of the DMH-PeF (1 ms pulses, 30–50 μA given at 100 Hz for 5 s) before and after the microinjection of kynurenic acid (non-specific glutamate receptor antagonist; 50 nl, 5 nmol), MK-801 (NMDA receptor antagonist; 50 nl, 50 nmol), CNQX (non-NMDA receptor antagonist; 50 nl, 50 nmol) or MCPG (metabotropic glutamate receptor antagonist; 50 nl, 5 nmol) within the A5 region. DMH-PeF electrical stimulation elicited a pressor ( p  < 0.001) and tachycardic response ( p  < 0.001) which was accompanied by an inspiratory facilitation characterised by an increase in respiratory rate ( p  < 0.001) due to a decrease in expiratory time ( p  < 0.01). Kynurenic acid within the A5 region decreased the tachycardia ( p  < 0.001) and the intensity of the blood pressure response ( p  < 0.001) to DMH-PeF stimulation. After the microinjection of MK-801 and CNQX into the A5 region, the magnitude of the tachycardia and the pressor response were decreased ( p  < 0.05 and p  < 0.01; p  < 0.001 and p  < 0.05, respectively). After MCPG microinjection into the A5 region, a decrease in the tachycardia ( p  < 0.001) with no changes in the pressor response was observed during DMH-PeF stimulation. The respiratory response elicited by DMH-PeF stimulation was not changed after the microinjection of kynurenic acid, MK-801, CNQX or MCPG within the A5 region. These results suggest that A5 region glutamate receptors play a role in the cardiovascular response elicited from the DMH-PeF. The possible mechanisms involved in these interactions are discussed.]]></description><identifier>ISSN: 1138-7548</identifier><identifier>EISSN: 1877-8755</identifier><identifier>DOI: 10.1007/s13105-018-0623-3</identifier><identifier>PMID: 29577176</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject><![CDATA[6-Cyano-7-nitroquinoxaline-2,3-dione - administration & dosage ; Animal Physiology ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Blood Pressure ; Cardiac arrhythmia ; Cardiovascular Physiological Phenomena ; Cardiovascular system ; Dizocilpine ; Dizocilpine Maleate - administration & dosage ; Dorsomedial Hypothalamic Nucleus - physiology ; Electric Stimulation ; Electrical stimuli ; Excitatory Amino Acid Antagonists - administration & dosage ; Fornix, Brain - physiology ; Glutamic acid receptors (ionotropic) ; Glutamic acid receptors (metabotropic) ; Glycine - administration & dosage ; Glycine - analogs & derivatives ; Heart Rate ; Human Physiology ; Hypothalamus ; Kynurenic acid ; Kynurenic Acid - administration & dosage ; Male ; Microinjection ; Microinjections ; N-Methyl-D-aspartic acid receptors ; Nuclei ; Original Article ; Rats ; Receptors ; Receptors, Glutamate - physiology ; Respiration ; Respiratory Rate ; Stimulation ; Tachycardia ; Tachycardia - physiopathology]]></subject><ispartof>Journal of physiology and biochemistry, 2018-05, Vol.74 (2), p.325-334</ispartof><rights>University of Navarra 2018</rights><rights>2018© University of Navarra 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-529438463accd258f93e473419906482d3dad696dc2259fa079b5ba972c1595d3</citedby><cites>FETCH-LOGICAL-c372t-529438463accd258f93e473419906482d3dad696dc2259fa079b5ba972c1595d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29577176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>López-González, M. V.</creatorcontrib><creatorcontrib>Díaz-Casares, A.</creatorcontrib><creatorcontrib>González-García, M.</creatorcontrib><creatorcontrib>Peinado-Aragonés, C. A.</creatorcontrib><creatorcontrib>Barbancho, M. A.</creatorcontrib><creatorcontrib>Carrillo de Albornoz, M.</creatorcontrib><creatorcontrib>Dawid-Milner, M. S.</creatorcontrib><title>Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area</title><title>Journal of physiology and biochemistry</title><addtitle>J Physiol Biochem</addtitle><addtitle>J Physiol Biochem</addtitle><description><![CDATA[To assess the possible function of glutamate in the interaction between the dorsomedial hypothalamic nucleus-perifornical area (DMH-PeF) and the A5 pontine region (A5), cardiovascular and respiratory changes were studied in response to electrical stimulation of the DMH-PeF (1 ms pulses, 30–50 μA given at 100 Hz for 5 s) before and after the microinjection of kynurenic acid (non-specific glutamate receptor antagonist; 50 nl, 5 nmol), MK-801 (NMDA receptor antagonist; 50 nl, 50 nmol), CNQX (non-NMDA receptor antagonist; 50 nl, 50 nmol) or MCPG (metabotropic glutamate receptor antagonist; 50 nl, 5 nmol) within the A5 region. DMH-PeF electrical stimulation elicited a pressor ( p  < 0.001) and tachycardic response ( p  < 0.001) which was accompanied by an inspiratory facilitation characterised by an increase in respiratory rate ( p  < 0.001) due to a decrease in expiratory time ( p  < 0.01). Kynurenic acid within the A5 region decreased the tachycardia ( p  < 0.001) and the intensity of the blood pressure response ( p  < 0.001) to DMH-PeF stimulation. After the microinjection of MK-801 and CNQX into the A5 region, the magnitude of the tachycardia and the pressor response were decreased ( p  < 0.05 and p  < 0.01; p  < 0.001 and p  < 0.05, respectively). After MCPG microinjection into the A5 region, a decrease in the tachycardia ( p  < 0.001) with no changes in the pressor response was observed during DMH-PeF stimulation. The respiratory response elicited by DMH-PeF stimulation was not changed after the microinjection of kynurenic acid, MK-801, CNQX or MCPG within the A5 region. These results suggest that A5 region glutamate receptors play a role in the cardiovascular response elicited from the DMH-PeF. The possible mechanisms involved in these interactions are discussed.]]></description><subject>6-Cyano-7-nitroquinoxaline-2,3-dione - administration &amp; dosage</subject><subject>Animal Physiology</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood Pressure</subject><subject>Cardiac arrhythmia</subject><subject>Cardiovascular Physiological Phenomena</subject><subject>Cardiovascular system</subject><subject>Dizocilpine</subject><subject>Dizocilpine Maleate - administration &amp; dosage</subject><subject>Dorsomedial Hypothalamic Nucleus - physiology</subject><subject>Electric Stimulation</subject><subject>Electrical stimuli</subject><subject>Excitatory Amino Acid Antagonists - administration &amp; dosage</subject><subject>Fornix, Brain - physiology</subject><subject>Glutamic acid receptors (ionotropic)</subject><subject>Glutamic acid receptors (metabotropic)</subject><subject>Glycine - administration &amp; dosage</subject><subject>Glycine - analogs &amp; derivatives</subject><subject>Heart Rate</subject><subject>Human Physiology</subject><subject>Hypothalamus</subject><subject>Kynurenic acid</subject><subject>Kynurenic Acid - administration &amp; dosage</subject><subject>Male</subject><subject>Microinjection</subject><subject>Microinjections</subject><subject>N-Methyl-D-aspartic acid receptors</subject><subject>Nuclei</subject><subject>Original Article</subject><subject>Rats</subject><subject>Receptors</subject><subject>Receptors, Glutamate - physiology</subject><subject>Respiration</subject><subject>Respiratory Rate</subject><subject>Stimulation</subject><subject>Tachycardia</subject><subject>Tachycardia - physiopathology</subject><issn>1138-7548</issn><issn>1877-8755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kc1u1TAQhS0Eoj_wAGwqS92wSfFvbC-rCtpKlbqBtTXXnvSmJHFqJ5X6EH1nfLmFSkisPPZ853g0h5BPnJ1xxsyXwiVnumHcNqwVspFvyCG3xjTWaP221lzaxmhlD8hRKfeMKcEFe08OhNPGcNMekufLYV1ghAVpxoDzknKhqaPLFum5rm93fZromOI67JgAOfbpEUqo91zbZU5TwULxMf3ESLucxt_aWH3SiLGHgW6f5rRsYYCxD3Raw4BroTBFOmPuu5SnPlQKMsIH8q6DoeDHl_OY_Pj29fvFVXNze3l9cX7TBGnE0mjhlLSqlRBCFNp2TqIyUnHnWKusiDJCbF0bgxDadcCM2-gNOCMC105HeUw-733nnB5WLIsf-xJwGGDCtBYv6krb1mmuK3r6D3qf1jzV6SqllGLKSl4pvqdCTqVk7Pyc-xHyk-fM77Ly-6x8Nfa7rLysmpMX53VTN_VX8SecCog9UGprusP8-vX_XX8BPsKghA</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>López-González, M. 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V.</creatorcontrib><creatorcontrib>Díaz-Casares, A.</creatorcontrib><creatorcontrib>González-García, M.</creatorcontrib><creatorcontrib>Peinado-Aragonés, C. A.</creatorcontrib><creatorcontrib>Barbancho, M. A.</creatorcontrib><creatorcontrib>Carrillo de Albornoz, M.</creatorcontrib><creatorcontrib>Dawid-Milner, M. S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of physiology and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>López-González, M. V.</au><au>Díaz-Casares, A.</au><au>González-García, M.</au><au>Peinado-Aragonés, C. A.</au><au>Barbancho, M. A.</au><au>Carrillo de Albornoz, M.</au><au>Dawid-Milner, M. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area</atitle><jtitle>Journal of physiology and biochemistry</jtitle><stitle>J Physiol Biochem</stitle><addtitle>J Physiol Biochem</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>74</volume><issue>2</issue><spage>325</spage><epage>334</epage><pages>325-334</pages><issn>1138-7548</issn><eissn>1877-8755</eissn><abstract><![CDATA[To assess the possible function of glutamate in the interaction between the dorsomedial hypothalamic nucleus-perifornical area (DMH-PeF) and the A5 pontine region (A5), cardiovascular and respiratory changes were studied in response to electrical stimulation of the DMH-PeF (1 ms pulses, 30–50 μA given at 100 Hz for 5 s) before and after the microinjection of kynurenic acid (non-specific glutamate receptor antagonist; 50 nl, 5 nmol), MK-801 (NMDA receptor antagonist; 50 nl, 50 nmol), CNQX (non-NMDA receptor antagonist; 50 nl, 50 nmol) or MCPG (metabotropic glutamate receptor antagonist; 50 nl, 5 nmol) within the A5 region. DMH-PeF electrical stimulation elicited a pressor ( p  < 0.001) and tachycardic response ( p  < 0.001) which was accompanied by an inspiratory facilitation characterised by an increase in respiratory rate ( p  < 0.001) due to a decrease in expiratory time ( p  < 0.01). Kynurenic acid within the A5 region decreased the tachycardia ( p  < 0.001) and the intensity of the blood pressure response ( p  < 0.001) to DMH-PeF stimulation. After the microinjection of MK-801 and CNQX into the A5 region, the magnitude of the tachycardia and the pressor response were decreased ( p  < 0.05 and p  < 0.01; p  < 0.001 and p  < 0.05, respectively). After MCPG microinjection into the A5 region, a decrease in the tachycardia ( p  < 0.001) with no changes in the pressor response was observed during DMH-PeF stimulation. The respiratory response elicited by DMH-PeF stimulation was not changed after the microinjection of kynurenic acid, MK-801, CNQX or MCPG within the A5 region. These results suggest that A5 region glutamate receptors play a role in the cardiovascular response elicited from the DMH-PeF. The possible mechanisms involved in these interactions are discussed.]]></abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>29577176</pmid><doi>10.1007/s13105-018-0623-3</doi><tpages>10</tpages></addata></record>
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ispartof Journal of physiology and biochemistry, 2018-05, Vol.74 (2), p.325-334
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1877-8755
language eng
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source Springer Nature
subjects 6-Cyano-7-nitroquinoxaline-2,3-dione - administration & dosage
Animal Physiology
Animals
Biomedical and Life Sciences
Biomedicine
Blood Pressure
Cardiac arrhythmia
Cardiovascular Physiological Phenomena
Cardiovascular system
Dizocilpine
Dizocilpine Maleate - administration & dosage
Dorsomedial Hypothalamic Nucleus - physiology
Electric Stimulation
Electrical stimuli
Excitatory Amino Acid Antagonists - administration & dosage
Fornix, Brain - physiology
Glutamic acid receptors (ionotropic)
Glutamic acid receptors (metabotropic)
Glycine - administration & dosage
Glycine - analogs & derivatives
Heart Rate
Human Physiology
Hypothalamus
Kynurenic acid
Kynurenic Acid - administration & dosage
Male
Microinjection
Microinjections
N-Methyl-D-aspartic acid receptors
Nuclei
Original Article
Rats
Receptors
Receptors, Glutamate - physiology
Respiration
Respiratory Rate
Stimulation
Tachycardia
Tachycardia - physiopathology
title Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area
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