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Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area
To assess the possible function of glutamate in the interaction between the dorsomedial hypothalamic nucleus-perifornical area (DMH-PeF) and the A5 pontine region (A5), cardiovascular and respiratory changes were studied in response to electrical stimulation of the DMH-PeF (1 ms pulses, 30–50 μA giv...
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Published in: | Journal of physiology and biochemistry 2018-05, Vol.74 (2), p.325-334 |
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container_title | Journal of physiology and biochemistry |
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creator | López-González, M. V. Díaz-Casares, A. González-García, M. Peinado-Aragonés, C. A. Barbancho, M. A. Carrillo de Albornoz, M. Dawid-Milner, M. S. |
description | To assess the possible function of glutamate in the interaction between the dorsomedial hypothalamic nucleus-perifornical area (DMH-PeF) and the A5 pontine region (A5), cardiovascular and respiratory changes were studied in response to electrical stimulation of the DMH-PeF (1 ms pulses, 30–50 μA given at 100 Hz for 5 s) before and after the microinjection of kynurenic acid (non-specific glutamate receptor antagonist; 50 nl, 5 nmol), MK-801 (NMDA receptor antagonist; 50 nl, 50 nmol), CNQX (non-NMDA receptor antagonist; 50 nl, 50 nmol) or MCPG (metabotropic glutamate receptor antagonist; 50 nl, 5 nmol) within the A5 region. DMH-PeF electrical stimulation elicited a pressor (
p
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doi_str_mv | 10.1007/s13105-018-0623-3 |
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p
< 0.001) and tachycardic response (
p
< 0.001) which was accompanied by an inspiratory facilitation characterised by an increase in respiratory rate (
p
< 0.001) due to a decrease in expiratory time (
p
< 0.01). Kynurenic acid within the A5 region decreased the tachycardia (
p
< 0.001) and the intensity of the blood pressure response (
p
< 0.001) to DMH-PeF stimulation. After the microinjection of MK-801 and CNQX into the A5 region, the magnitude of the tachycardia and the pressor response were decreased (
p
< 0.05 and
p
< 0.01;
p
< 0.001 and
p
< 0.05, respectively). After MCPG microinjection into the A5 region, a decrease in the tachycardia (
p
< 0.001) with no changes in the pressor response was observed during DMH-PeF stimulation. The respiratory response elicited by DMH-PeF stimulation was not changed after the microinjection of kynurenic acid, MK-801, CNQX or MCPG within the A5 region. These results suggest that A5 region glutamate receptors play a role in the cardiovascular response elicited from the DMH-PeF. The possible mechanisms involved in these interactions are discussed.]]></description><identifier>ISSN: 1138-7548</identifier><identifier>EISSN: 1877-8755</identifier><identifier>DOI: 10.1007/s13105-018-0623-3</identifier><identifier>PMID: 29577176</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject><![CDATA[6-Cyano-7-nitroquinoxaline-2,3-dione - administration & dosage ; Animal Physiology ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Blood Pressure ; Cardiac arrhythmia ; Cardiovascular Physiological Phenomena ; Cardiovascular system ; Dizocilpine ; Dizocilpine Maleate - administration & dosage ; Dorsomedial Hypothalamic Nucleus - physiology ; Electric Stimulation ; Electrical stimuli ; Excitatory Amino Acid Antagonists - administration & dosage ; Fornix, Brain - physiology ; Glutamic acid receptors (ionotropic) ; Glutamic acid receptors (metabotropic) ; Glycine - administration & dosage ; Glycine - analogs & derivatives ; Heart Rate ; Human Physiology ; Hypothalamus ; Kynurenic acid ; Kynurenic Acid - administration & dosage ; Male ; Microinjection ; Microinjections ; N-Methyl-D-aspartic acid receptors ; Nuclei ; Original Article ; Rats ; Receptors ; Receptors, Glutamate - physiology ; Respiration ; Respiratory Rate ; Stimulation ; Tachycardia ; Tachycardia - physiopathology]]></subject><ispartof>Journal of physiology and biochemistry, 2018-05, Vol.74 (2), p.325-334</ispartof><rights>University of Navarra 2018</rights><rights>2018© University of Navarra 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-529438463accd258f93e473419906482d3dad696dc2259fa079b5ba972c1595d3</citedby><cites>FETCH-LOGICAL-c372t-529438463accd258f93e473419906482d3dad696dc2259fa079b5ba972c1595d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29577176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>López-González, M. V.</creatorcontrib><creatorcontrib>Díaz-Casares, A.</creatorcontrib><creatorcontrib>González-García, M.</creatorcontrib><creatorcontrib>Peinado-Aragonés, C. A.</creatorcontrib><creatorcontrib>Barbancho, M. A.</creatorcontrib><creatorcontrib>Carrillo de Albornoz, M.</creatorcontrib><creatorcontrib>Dawid-Milner, M. S.</creatorcontrib><title>Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area</title><title>Journal of physiology and biochemistry</title><addtitle>J Physiol Biochem</addtitle><addtitle>J Physiol Biochem</addtitle><description><![CDATA[To assess the possible function of glutamate in the interaction between the dorsomedial hypothalamic nucleus-perifornical area (DMH-PeF) and the A5 pontine region (A5), cardiovascular and respiratory changes were studied in response to electrical stimulation of the DMH-PeF (1 ms pulses, 30–50 μA given at 100 Hz for 5 s) before and after the microinjection of kynurenic acid (non-specific glutamate receptor antagonist; 50 nl, 5 nmol), MK-801 (NMDA receptor antagonist; 50 nl, 50 nmol), CNQX (non-NMDA receptor antagonist; 50 nl, 50 nmol) or MCPG (metabotropic glutamate receptor antagonist; 50 nl, 5 nmol) within the A5 region. DMH-PeF electrical stimulation elicited a pressor (
p
< 0.001) and tachycardic response (
p
< 0.001) which was accompanied by an inspiratory facilitation characterised by an increase in respiratory rate (
p
< 0.001) due to a decrease in expiratory time (
p
< 0.01). Kynurenic acid within the A5 region decreased the tachycardia (
p
< 0.001) and the intensity of the blood pressure response (
p
< 0.001) to DMH-PeF stimulation. After the microinjection of MK-801 and CNQX into the A5 region, the magnitude of the tachycardia and the pressor response were decreased (
p
< 0.05 and
p
< 0.01;
p
< 0.001 and
p
< 0.05, respectively). After MCPG microinjection into the A5 region, a decrease in the tachycardia (
p
< 0.001) with no changes in the pressor response was observed during DMH-PeF stimulation. The respiratory response elicited by DMH-PeF stimulation was not changed after the microinjection of kynurenic acid, MK-801, CNQX or MCPG within the A5 region. These results suggest that A5 region glutamate receptors play a role in the cardiovascular response elicited from the DMH-PeF. The possible mechanisms involved in these interactions are discussed.]]></description><subject>6-Cyano-7-nitroquinoxaline-2,3-dione - administration & dosage</subject><subject>Animal Physiology</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood Pressure</subject><subject>Cardiac arrhythmia</subject><subject>Cardiovascular Physiological Phenomena</subject><subject>Cardiovascular system</subject><subject>Dizocilpine</subject><subject>Dizocilpine Maleate - administration & dosage</subject><subject>Dorsomedial Hypothalamic Nucleus - physiology</subject><subject>Electric Stimulation</subject><subject>Electrical stimuli</subject><subject>Excitatory Amino Acid Antagonists - administration & dosage</subject><subject>Fornix, Brain - physiology</subject><subject>Glutamic acid receptors (ionotropic)</subject><subject>Glutamic acid receptors (metabotropic)</subject><subject>Glycine - administration & dosage</subject><subject>Glycine - analogs & derivatives</subject><subject>Heart Rate</subject><subject>Human Physiology</subject><subject>Hypothalamus</subject><subject>Kynurenic acid</subject><subject>Kynurenic Acid - administration & dosage</subject><subject>Male</subject><subject>Microinjection</subject><subject>Microinjections</subject><subject>N-Methyl-D-aspartic acid receptors</subject><subject>Nuclei</subject><subject>Original Article</subject><subject>Rats</subject><subject>Receptors</subject><subject>Receptors, Glutamate - physiology</subject><subject>Respiration</subject><subject>Respiratory Rate</subject><subject>Stimulation</subject><subject>Tachycardia</subject><subject>Tachycardia - physiopathology</subject><issn>1138-7548</issn><issn>1877-8755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kc1u1TAQhS0Eoj_wAGwqS92wSfFvbC-rCtpKlbqBtTXXnvSmJHFqJ5X6EH1nfLmFSkisPPZ853g0h5BPnJ1xxsyXwiVnumHcNqwVspFvyCG3xjTWaP221lzaxmhlD8hRKfeMKcEFe08OhNPGcNMekufLYV1ghAVpxoDzknKhqaPLFum5rm93fZromOI67JgAOfbpEUqo91zbZU5TwULxMf3ESLucxt_aWH3SiLGHgW6f5rRsYYCxD3Raw4BroTBFOmPuu5SnPlQKMsIH8q6DoeDHl_OY_Pj29fvFVXNze3l9cX7TBGnE0mjhlLSqlRBCFNp2TqIyUnHnWKusiDJCbF0bgxDadcCM2-gNOCMC105HeUw-733nnB5WLIsf-xJwGGDCtBYv6krb1mmuK3r6D3qf1jzV6SqllGLKSl4pvqdCTqVk7Pyc-xHyk-fM77Ly-6x8Nfa7rLysmpMX53VTN_VX8SecCog9UGprusP8-vX_XX8BPsKghA</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>López-González, M. V.</creator><creator>Díaz-Casares, A.</creator><creator>González-García, M.</creator><creator>Peinado-Aragonés, C. A.</creator><creator>Barbancho, M. A.</creator><creator>Carrillo de Albornoz, M.</creator><creator>Dawid-Milner, M. S.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180501</creationdate><title>Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area</title><author>López-González, M. V. ; Díaz-Casares, A. ; González-García, M. ; Peinado-Aragonés, C. A. ; Barbancho, M. A. ; Carrillo de Albornoz, M. ; Dawid-Milner, M. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-529438463accd258f93e473419906482d3dad696dc2259fa079b5ba972c1595d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>6-Cyano-7-nitroquinoxaline-2,3-dione - administration & dosage</topic><topic>Animal Physiology</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood Pressure</topic><topic>Cardiac arrhythmia</topic><topic>Cardiovascular Physiological Phenomena</topic><topic>Cardiovascular system</topic><topic>Dizocilpine</topic><topic>Dizocilpine Maleate - administration & dosage</topic><topic>Dorsomedial Hypothalamic Nucleus - physiology</topic><topic>Electric Stimulation</topic><topic>Electrical stimuli</topic><topic>Excitatory Amino Acid Antagonists - administration & dosage</topic><topic>Fornix, Brain - physiology</topic><topic>Glutamic acid receptors (ionotropic)</topic><topic>Glutamic acid receptors (metabotropic)</topic><topic>Glycine - administration & dosage</topic><topic>Glycine - analogs & derivatives</topic><topic>Heart Rate</topic><topic>Human Physiology</topic><topic>Hypothalamus</topic><topic>Kynurenic acid</topic><topic>Kynurenic Acid - administration & dosage</topic><topic>Male</topic><topic>Microinjection</topic><topic>Microinjections</topic><topic>N-Methyl-D-aspartic acid receptors</topic><topic>Nuclei</topic><topic>Original Article</topic><topic>Rats</topic><topic>Receptors</topic><topic>Receptors, Glutamate - physiology</topic><topic>Respiration</topic><topic>Respiratory Rate</topic><topic>Stimulation</topic><topic>Tachycardia</topic><topic>Tachycardia - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>López-González, M. V.</creatorcontrib><creatorcontrib>Díaz-Casares, A.</creatorcontrib><creatorcontrib>González-García, M.</creatorcontrib><creatorcontrib>Peinado-Aragonés, C. A.</creatorcontrib><creatorcontrib>Barbancho, M. A.</creatorcontrib><creatorcontrib>Carrillo de Albornoz, M.</creatorcontrib><creatorcontrib>Dawid-Milner, M. S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of physiology and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>López-González, M. V.</au><au>Díaz-Casares, A.</au><au>González-García, M.</au><au>Peinado-Aragonés, C. A.</au><au>Barbancho, M. A.</au><au>Carrillo de Albornoz, M.</au><au>Dawid-Milner, M. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area</atitle><jtitle>Journal of physiology and biochemistry</jtitle><stitle>J Physiol Biochem</stitle><addtitle>J Physiol Biochem</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>74</volume><issue>2</issue><spage>325</spage><epage>334</epage><pages>325-334</pages><issn>1138-7548</issn><eissn>1877-8755</eissn><abstract><![CDATA[To assess the possible function of glutamate in the interaction between the dorsomedial hypothalamic nucleus-perifornical area (DMH-PeF) and the A5 pontine region (A5), cardiovascular and respiratory changes were studied in response to electrical stimulation of the DMH-PeF (1 ms pulses, 30–50 μA given at 100 Hz for 5 s) before and after the microinjection of kynurenic acid (non-specific glutamate receptor antagonist; 50 nl, 5 nmol), MK-801 (NMDA receptor antagonist; 50 nl, 50 nmol), CNQX (non-NMDA receptor antagonist; 50 nl, 50 nmol) or MCPG (metabotropic glutamate receptor antagonist; 50 nl, 5 nmol) within the A5 region. DMH-PeF electrical stimulation elicited a pressor (
p
< 0.001) and tachycardic response (
p
< 0.001) which was accompanied by an inspiratory facilitation characterised by an increase in respiratory rate (
p
< 0.001) due to a decrease in expiratory time (
p
< 0.01). Kynurenic acid within the A5 region decreased the tachycardia (
p
< 0.001) and the intensity of the blood pressure response (
p
< 0.001) to DMH-PeF stimulation. After the microinjection of MK-801 and CNQX into the A5 region, the magnitude of the tachycardia and the pressor response were decreased (
p
< 0.05 and
p
< 0.01;
p
< 0.001 and
p
< 0.05, respectively). After MCPG microinjection into the A5 region, a decrease in the tachycardia (
p
< 0.001) with no changes in the pressor response was observed during DMH-PeF stimulation. The respiratory response elicited by DMH-PeF stimulation was not changed after the microinjection of kynurenic acid, MK-801, CNQX or MCPG within the A5 region. These results suggest that A5 region glutamate receptors play a role in the cardiovascular response elicited from the DMH-PeF. The possible mechanisms involved in these interactions are discussed.]]></abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>29577176</pmid><doi>10.1007/s13105-018-0623-3</doi><tpages>10</tpages></addata></record> |
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source | Springer Nature |
subjects | 6-Cyano-7-nitroquinoxaline-2,3-dione - administration & dosage Animal Physiology Animals Biomedical and Life Sciences Biomedicine Blood Pressure Cardiac arrhythmia Cardiovascular Physiological Phenomena Cardiovascular system Dizocilpine Dizocilpine Maleate - administration & dosage Dorsomedial Hypothalamic Nucleus - physiology Electric Stimulation Electrical stimuli Excitatory Amino Acid Antagonists - administration & dosage Fornix, Brain - physiology Glutamic acid receptors (ionotropic) Glutamic acid receptors (metabotropic) Glycine - administration & dosage Glycine - analogs & derivatives Heart Rate Human Physiology Hypothalamus Kynurenic acid Kynurenic Acid - administration & dosage Male Microinjection Microinjections N-Methyl-D-aspartic acid receptors Nuclei Original Article Rats Receptors Receptors, Glutamate - physiology Respiration Respiratory Rate Stimulation Tachycardia Tachycardia - physiopathology |
title | Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area |
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