Central irisin administration suppresses thyroid hormone production but increases energy consumption in rats

• Published in: Neuroscience letters 2018-05, Vol.674, p.136-141
• Main Authors: Tekin, Suat, Erden, Yavuz, Ozyalin, Fatma, Onalan, Ebru Etem, Cigremis, Yilmaz, Colak, Cemil, Tekedereli, Ibrahim, Sandal, Suleyman
• Format: Article
• Language: English
• Subjects: Energy metabolism; HPT axis; Irisin; Thyroid hormones; Uncoupling proteins
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/j.neulet.2018.03.046

•Irisin infusion increased food intake in rats.•Irisin infusion decreased the thyroid hormone levels, but increased the body temperature.•Infusion of irisin increased UCP1 in adipose tissues and UCP3 mRNA levels in muscle tissue. Irisin, which is secreted from the skeletal muscle in response to physical exercise and defined as a thermogenic peptide, may play an important role in energy metabolism. Thyroid hormones, which are one of the other influential factors on the metabolic status, increase heat production and are the main regulators of energy metabolism. This study was conducted to determine the possible effects of irisin administration on thyroid hormones. Forty adult male Wistar albino rats were used in the study. The rats were equally divided into 4 groups (n = 10). The brain infusion kit was implanted in the groups, and irisin (or solvent as control) was centrally administered to the rats via osmotic mini pumps for 7 days. During the experiment, food consumption, body weights, and body temperatures of the animals were recorded. Food intake was significantly increased in the groups treated with irisin (p