Molecular biological analysis in a patient with multiple lung adenocarcinomas

The utility of molecular biological analysis in lung adenocarcinoma has been demonstrated. Herein we report a rare case presenting as multiple lung adenocarcinomas with four different EGFR gene mutations detected in three lung tumors. After opacification was detected by routine chest X-ray, the pati...

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Bibliographic Details
Published in:Thoracic cancer 2018, Vol.9 (5), p.662-665
Main Authors: Wakayama, Tomoshige, Hirata, Hirokuni, Suka, Shunsuke, Sato, Kozo, Tatewaki, Masamitsu, Souma, Ryosuke, Satoh, Hideyuki, Tamura, Motohiko, Matsumura, Yuji, Imada, Hiroki, Sugiyama, Kumiya, Arima, Masafumi, Kurasawa, Kazuhiro, Fukuda, Takeshi, Fukushima, Yasutsugu
Format: Report
Language:English
Online Access:Get full text
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Summary:The utility of molecular biological analysis in lung adenocarcinoma has been demonstrated. Herein we report a rare case presenting as multiple lung adenocarcinomas with four different EGFR gene mutations detected in three lung tumors. After opacification was detected by routine chest X-ray, the patient, a 64-year-old woman, underwent chest computed tomography which revealed a right lung segment S4 ground-glass nodule (GGN). Follow-up computed tomography revealed a 42 mm GGN nodule with a 26 mm nodule (S6) and a 20 mm GGN (S10). Histopathology of resected specimens from the right middle and lower lobes revealed all three nodules were adenocarcinomas. Four EGFR mutations were detected; no three tumors had the same mutations. Molecular biological analysis is a promising tool for the diagnosis of primary tumors in patients with multiple lung carcinomas of the same histotype, enabling appropriate treatment.
ISSN:1759-7714
DOI:10.1111/1759-7714.12634