Assessing Asthma Medication Responses in U.S. Minority Children by Whole-Genome Sequencing

To maximize study power, Mak and colleagues (6) selected approximately equal numbers of patients from three minority populations (Puerto Ricans, Mexicans, and African Americans) from both tails of the BDR distribution, summing up a total of 1,441 children with asthma who were subjected to WGS. On th...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2018-06, Vol.197 (12), p.1513-1514
Main Authors: Lorenzo-Salazar, José M, Flores, Carlos
Format: Article
Language:English
Subjects:
African Americans
Anti-Asthmatic Agents
Asthma
Child
Children & youth
Chronic obstructive pulmonary disease
Consortia
Disease
Genetics
Genomes
Genomics
Humans
Independent study
Minority & ethnic groups
Minority Groups
Pharmacogenetics
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Summary:To maximize study power, Mak and colleagues (6) selected approximately equal numbers of patients from three minority populations (Puerto Ricans, Mexicans, and African Americans) from both tails of the BDR distribution, summing up a total of 1,441 children with asthma who were subjected to WGS. On the downside, the study exemplifies the obstacles of applying WGS in complex traits at the present time: most prominently, the sacrifice of study power, the scarcity of independent studies with sequencing data available for replication, the lack of gold standard bioinformatics and statistical methods to deal with all types of genetic variants and variant grouping strategies, and the limited understanding of sequence element functions and their genome reach to help interpreting the results. Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, et al.; Mexico City Childhood Asthma Study (MCAAS); Children's Health Study (CHS) and HARBORS study; Genetics of Asthma in Latino Americans (GALA) Study, Study of Genes-Environment and Admixture in Latino Americans (GALA2) and Study of African Americans, Asthma, Genes & Environments (SAGE); Childhood Asthma Research and Education (CARE) Network; Childhood Asthma Management Program (CAMP); Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE); Genetic Research on Asthma in African Diaspora (GRAAD) Study.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201803-0457ED