Subclinical left ventricular dysfunction and correlation with regional strain analysis in myocarditis with normal ejection fraction. A new diagnostic criterion

• Published in: International journal of cardiology 2018-05, Vol.259, p.116-121
• Main Authors: Kostakou, Peggy M., Kostopoulos, Vassilis S., Tryfou, Elsi S., Giannaris, Vassilis D., Rodis, Ioannis E., Olympios, Christoforos D., Kouris, Nikos T.
• Format: Article
• Language: English
• Subjects: Cardiac magnetic resonance; Lateral wall; Myocarditis; Speckle tracking
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/j.ijcard.2018.01.058

The diagnosis of myocarditis is challenging, especially in case of normal left ventricular systolic function. The aim of this study is to test the hypothesis that 2D speckle tracking echocardiography (2DSTE) can detect subclinical left ventricular (LV) dysfunction in patients with myocarditis and preserved LV function without regional wall motion abnormalities and that regional strain analysis can correlate with cardiac magnetic resonance (CMR) findings. Study population consisted of 25 consecutive patients with myocarditis and 19 controls. All patients underwent a full echocardiographic study at the first day of their admission and in addition to conventional echocardiographic measurements, global longitudinal and circumferential strain of the left ventricle (LVGLS, LVCS accordingly), as well as regional strains of the lateral wall, were estimated. Moreover, all patients underwent a CMR scan during the first week from their admission. Although there was no statistical difference between the two groups of patients in systolic function, myocarditis patients demonstrated significantly impaired LVGLS (−16.5 ± 2.2 vs −20.5 ± 1.3%, p