Ribavirin Had Demonstrable Effects on the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Population and Load in a Patient With CCHF Infection

The use of ribavirin to treat Crimean-Congo hemorrhagic fever virus (CCHFV) infection has been controversial, based on uncertainties about its antiviral efficacy in clinical case studies. We studied the effect of ribavirin treatment on viral populations in a recent case by deep-sequencing analysis o...

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Bibliographic Details
Published in:The Journal of infectious diseases 2018-05, Vol.217 (12), p.1952-1956
Main Authors: Espy, Nicole, Pérez-Sautu, Unai, Ramírez de Arellano, Eva, Negredo, Anabel, Wiley, Michael R, Bavari, Sina, Díaz Menendez, Marta, Sánchez-Seco, María Paz, Palacios, Gustavo
Format: Article
Language:English
Subjects:
Antibodies, Viral - immunology
Antiviral Agents - immunology
Hemorrhagic Fever Virus, Crimean-Congo - drug effects
Hemorrhagic Fever Virus, Crimean-Congo - immunology
Hemorrhagic Fever, Crimean - drug therapy
Hemorrhagic Fever, Crimean - immunology
Humans
Ribavirin - therapeutic use
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Summary:The use of ribavirin to treat Crimean-Congo hemorrhagic fever virus (CCHFV) infection has been controversial, based on uncertainties about its antiviral efficacy in clinical case studies. We studied the effect of ribavirin treatment on viral populations in a recent case by deep-sequencing analysis of plasma samples obtained from a CCHFV-infected patient before, during, and after a 5-day regimen of ribavirin treatment. The CCHFV load dropped during ribavirin treatment, and subclonal diversity (transitions) and indels increased in viral genomes during treatment. Although the results are based on a single case, these data demonstrate the mutagenic effect of ribavirin on CCHFV in vivo.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiy163