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Quality before Quantity: Inspecting CFTR

CFTR biosynthesis is highly dynamic. In this issue of Developmental Cell, Okiyoneda et al. (2018) show that RFFL serves as a CFTR conformation scrutinizer at the plasma membrane. It recognizes misfolded CFTR proteins and marks them for degradation. This quality control mechanism may be explored to b...

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Bibliographic Details
Published in:Developmental cell 2018-03, Vol.44 (6), p.655-656
Main Author: Mou, Hongmei
Format: Article
Language:English
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Summary:CFTR biosynthesis is highly dynamic. In this issue of Developmental Cell, Okiyoneda et al. (2018) show that RFFL serves as a CFTR conformation scrutinizer at the plasma membrane. It recognizes misfolded CFTR proteins and marks them for degradation. This quality control mechanism may be explored to benefit cystic fibrosis patients. CFTR biosynthesis is highly dynamic. In this issue of Developmental Cell, Okiyoneda et al. (2018) show that RFFL serves as a CFTR conformation scrutinizer at the plasma membrane. It recognizes misfolded CFTR proteins and marks them for degradation. This quality control mechanism may be explored to benefit cystic fibrosis patients.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2018.03.003