π‑Extended Benzoporphyrin-Based Metal–Organic Framework for Inhibition of Tumor Metastasis

We report on the benzoporphyrin-based metal–organic framework (TBP-MOF), with 10-connected Zr6 cluster and much improved photophysical properties over the traditional porphyrin-based MOFs. It was found that TBP-MOF exhibited red-shifted absorption bands and strong near-infrared luminescence for bioi...

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Bibliographic Details
Published in:ACS nano 2018-05, Vol.12 (5), p.4630-4640
Main Authors: Zeng, Jin-Yue, Zou, Mei-Zhen, Zhang, Mingkang, Wang, Xiao-Shuang, Zeng, Xuan, Cong, Hengjiang, Zhang, Xian-Zheng
Format: Article
Language:English
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Summary:We report on the benzoporphyrin-based metal–organic framework (TBP-MOF), with 10-connected Zr6 cluster and much improved photophysical properties over the traditional porphyrin-based MOFs. It was found that TBP-MOF exhibited red-shifted absorption bands and strong near-infrared luminescence for bioimaging, whereas the π-extended benzoporphyrin-based linkers of TBP-MOF facilitated 1O2 generation to enhance O2-dependent photodynamic therapy (PDT). It was demonstrated that poly­(ethylene glycol)-modified nanoscale TBP-MOF (TBP-nMOF) can be used as an effective PDT agent under hypoxic tumor microenvironment. We also elucidated that the low O2-dependent PDT of TBP-nMOF in combination with αPD-1 checkpoint blockade therapy can not only suppress the growth of primary tumor, but also stimulate an antitumor immune response for inhibiting metastatic tumor growth. We believe this TBP-nMOF has great potential to serve as an efficient photosensitizer for PDT and cancer immunotherapy.
ISSN:1936-0851
1936-086X
DOI:10.1021/acsnano.8b01186