Overview of Osteoimmunology

Aberrant or prolonged immune responses often affect bone metabolism. The investigation on bone destruction observed in autoimmune arthritis contributed to the development of research area on effect of the immune system on bone. A number of reports on bone phenotypes of immunocompromised mice indicat...

Full description

Saved in:
Bibliographic Details
Published in:Calcified tissue international 2018-05, Vol.102 (5), p.503-511
Main Authors: Terashima, Asuka, Takayanagi, Hiroshi
Format: Article
Language:English
Subjects:
Arthritis
Biochemistry
Biomedical and Life Sciences
Bone marrow
Bone turnover
Cell Biology
Endocrinology
Hematopoietic stem cells
Immune response
Immune system
Life Sciences
Orthopedics
Osteoprogenitor cells
Review
Transcription factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aberrant or prolonged immune responses often affect bone metabolism. The investigation on bone destruction observed in autoimmune arthritis contributed to the development of research area on effect of the immune system on bone. A number of reports on bone phenotypes of immunocompromised mice indicate that the immune and skeletal systems share various molecules, including transcription factors, signaling molecules, and membrane receptors, suggesting the interplay between the two systems. Furthermore, much attention has been paid to the modulation of immune cells, including hematopoietic progenitor cells, by bone cells in the bone marrow. Thus, osteoimmunology which deals with the crosstalk and shared mechanisms of the bone and immune systems became the conceptual framework fundamental to a proper understanding of both systems and the development of new therapeutic strategies.
ISSN:0171-967X
1432-0827
DOI:10.1007/s00223-018-0417-1