Clinical Impact of p27Kip1 and CaSR Expression on Primary Hyperparathyroidism

We aimed to investigate the expressions of p27 kinase inhibitory protein 1 ( p27 Kip1 ) and calcium sensing receptor (CaSR) in adenomas and normal parathyroid tissue and to evaluate the relationship of these molecules with clinical and biochemical parameters in primary hyperparathyroidism (PHPT). Fi...

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Bibliographic Details
Published in:Endocrine pathology 2018-09, Vol.29 (3), p.250-258
Main Authors: Sengul Aycicek, Gozde, Aydogan, Berna Imge, Sahin, Mustafa, Cansız Ersoz, Cevriye, Sak, Serpil Dizbay, Baskal, Nilgun
Format: Article
Language:English
Subjects:
Endocrinology
Medicine
Medicine & Public Health
Oncology
Pathology
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Summary:We aimed to investigate the expressions of p27 kinase inhibitory protein 1 ( p27 Kip1 ) and calcium sensing receptor (CaSR) in adenomas and normal parathyroid tissue and to evaluate the relationship of these molecules with clinical and biochemical parameters in primary hyperparathyroidism (PHPT). Fifty-one patients with histopathologically confirmed parathyroid adenomas and 20 patients with normal parathyroid glands (which were removed incidentally during thyroid resection) were included. Immunohistochemical stainings of CaSR and p27 Kip1 were performed in surgical specimens. Clinical features, biochemical parameters, and BMD measurements of patients with PHPT were evaluated retrospectively. Expressions of p27 Kip1 and CaSR were decreased in parathyroid adenomas, compared to normal glands ( p  
ISSN:1046-3976
1559-0097
DOI:10.1007/s12022-018-9524-9