Effect of Eicosapentaenoic acid (EPA) supplementation on cardiovascular markers in patients with type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial

Cardiovascular complications are one of main cause of increased mortality and morbidity among Diabetes Mellitus (DM) patients. Altered metabolism of sulphur amino acids in diabetes reflected as increases in concentration of methionine and cysteine/cystine in the blood which known as a markers of Car...

Full description

Saved in:
Bibliographic Details
Published in:Diabetes & metabolic syndrome clinical research & reviews 2018-05, Vol.12 (3), p.411-415
Main Authors: Golzari, Mohammad Hassan, Javanbakht, Mohammad Hassan, Ghaedi, Ehsan, Mohammadi, Hamed, Djalali, Mahmoud
Format: Article
Language:English
Subjects:
Cardiovascular markers
Diabetes mellitus
Eicosapentaenoic acid
Randomized clinical trial
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiovascular complications are one of main cause of increased mortality and morbidity among Diabetes Mellitus (DM) patients. Altered metabolism of sulphur amino acids in diabetes reflected as increases in concentration of methionine and cysteine/cystine in the blood which known as a markers of Cardiovascular Diseases (CVD). The aim of present study was to determine the effect of Eicosapentaenoic acid (EPA) supplementation on sulfhydryl amino acids and Atherogenic Index of Plasma (AIP) in patients with type 2 DM (T2DM). A randomized, double-blind, placebo-controlled clinical trial was performed in 36 control and patients with DM. The subjects were randomly assigned to obtain 2 g/d EPA (n = 18) or placebo (n = 18) for 8 weeks. Fasting serum level of Cystein and Methionine were measured using HPLC method and atherogenic index of plasma (AIP) as a proxy measure of atherosclerosis was computed. Eight weeks supplementation with EPA led to significant reductions in Met (p 
ISSN:1871-4021
1878-0334
DOI:10.1016/j.dsx.2018.03.003