Effects of Fish Oil on the Central Nervous System: A New Potential Antidepressant?

In the last 100 years major depression has increased worldwide. In this study we provided coconut fat (CF, rich in saturated fatty acids) or fish oil (FO, rich in n-3 polyunsaturated fatty acids) to female rats throughout pregnancy and lactation and then to their offspring post-weaning and examined...

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Bibliographic Details
Published in:Nutritional neuroscience 2004-04, Vol.7 (2), p.91-99
Main Authors: Naliwaiko, K., Araújo, R.L.F., da Fonseca, R.V., Castilho, J.C., Andreatini, R., Bellissimo, M.I., Oliveira, B.H., Martins, E.F., Curi, R., Fernandes, L.C., Ferraz, A.C.
Format: Article
Language:English
Subjects:
Animals
Antidepressive Agents - pharmacology
Cerebral Cortex - drug effects
Cerebral Cortex - physiology
Cerebral function
Depression
Dietary Supplements
Docosahexaenoic Acids - metabolism
Eicosapentaenoic Acid - metabolism
Female
Fish oil
Fish Oils - pharmacology
Forced swimming
Hippocampus - drug effects
Hippocampus - physiology
Lipid Peroxidation
Maze Learning - drug effects
Maze Learning - physiology
Milk - chemistry
Motor Activity - drug effects
Motor Activity - physiology
Polyunsaturated fatty acids
Rats
Rats, Wistar
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Summary:In the last 100 years major depression has increased worldwide. In this study we provided coconut fat (CF, rich in saturated fatty acids) or fish oil (FO, rich in n-3 polyunsaturated fatty acids) to female rats throughout pregnancy and lactation and then to their offspring post-weaning and examined lipid brain profile and the possible effect of FO as antidepressant agent in the offspring in adulthood (F1). Rats were submitted to forced swimming test, elevated plus maze, Morris water maze and open field. Peroxidation rate in the cerebral cortex and hippocampus were measured. Docosahexaenoic acid (DHA) concentration in dam's milk, eicosapentaenoic acid (EPA) and DHA concentration in hippocampus and cerebral cortex from F1 rats FO supplemented increased significantly when compared to control (C) and CF rats. Arachidonic acid/EPA ratio in the cerebral cortex and hippocampus decreased in rats submitted to forced swimming test. Peroxidation rate were not different between the groups. Immobility time in the forced swimming test in FO group was reduced (p
ISSN:1028-415X
1476-8305
DOI:10.1080/10284150410001704525