Photoelectrochemical immunoassay for human interleukin 6 based on the use of perovskite-type LaFeO3 nanoparticles on fluorine-doped tin oxide glass

A film of perovskite-type LaFeO 3 nanoparticles (NPs) was deposited on fluorine-doped tin oxide (FTO) conducting glass via dipping-lifting and calcination. Scanning electron microscopy shows that the NPs are evenly distributed on the surface of the glass. The modified glass was further coated with a...

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Bibliographic Details
Published in:Mikrochimica acta (1966) 2018-01, Vol.185 (1), p.1-6, Article 52
Main Authors: Liu, Xing-Pei, Xie, Xing-Li, Wei, Yu-Ping, Mao, Chang-jie, Chen, Jing-Shuai, Niu, He-Lin, Song, Ji-Ming, Jin, Bao-Kang
Format: Article
Language:English
Subjects:
Analytical Chemistry
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Cytokines
Electron microscopy
Fluorine
Immunoassay
Immunosensors
Interleukins
Microengineering
Nanochemistry
Nanoparticles
Nanotechnology
Original Paper
Scanning electron microscopy
Tin oxides
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Summary:A film of perovskite-type LaFeO 3 nanoparticles (NPs) was deposited on fluorine-doped tin oxide (FTO) conducting glass via dipping-lifting and calcination. Scanning electron microscopy shows that the NPs are evenly distributed on the surface of the glass. The modified glass was further coated with antibody against human interleukin 6 (IL-6) to result in a photoelectrochemical immunosensor for IL-6. The well-established photoelectrochemical immunoassay has a linear current response in the range of 0.1 pg·mL −1 to 0.1 μg·mL −1 and a detection limit as low as 33 fg·mL −1 . Graphical abstract Schematic of a novel photoelectochemical immunoassay for the measurement of IL-6 based on perovskite-type LaFeO3 nanoparticles. The immunoassay had a higher sensitivity and may also be applied to other bioanalysis and environment monitoring.
ISSN:0026-3672
1436-5073
DOI:10.1007/s00604-017-2554-z