Cripto-1 is overexpressed in carcinoma ex pleomorphic adenoma of salivary gland

• Published in: European archives of oto-rhino-laryngology 2018-06, Vol.275 (6), p.1595-1600
• Main Authors: Silva, Leorik Pereira, da Silva, Luiz Arthur Barbosa, Sedassari, Bruno Tavares, de Sousa, Suzana Cantanhede Orsini Machado, dos Santos Pereira, Joabe, de Souza, Lélia Batista, da Costa Miguel, Márcia Cristina
• Format: Article
• Language: English
• Subjects: Head and Neck; Head and Neck Surgery; Medicine; Medicine & Public Health; Neurosurgery; Otorhinolaryngology
• ISSN: 0937-4477; 1434-4726
• DOI: 10.1007/s00405-018-4960-1

Introduction Cripto-1 is a member of the epidermal growth factor—Cripto-1/FRL-1/Cryptic family. Besides being critical for early embryonic development, Cripto-1 is also associated with the development and behavior of several cancers. Objective: We analyzed the immunoexpression of Cripto-1 in normal salivary glands (NSGs), pleomorphic adenomas (PAs), and carcinoma ex pleomorphic adenomas (CaExPAs) of salivary glands. Methods A total of 12 NSGs, 16 PAs and 12 CaExPAs underwent immunohistochemical study by the polymeric biotin-free technique. Immunopositive cells were evaluated semiquantitatively (scores 0–3). For statistical analysis, Mann–Whitney and Kruskal–Wallis tests were performed and a significance level of p  ≤ 0.05 was established. Results Most CaExPAs ( n  = 10) were strong positive (score 3) for Cripto-1, and only three cases of PAs and two specimens of NSGs exhibited some expression (score 1), being statistically significant these findings ( p