Carbon nanotube-modified monolithic polymethacrylate pipette tips for (micro)solid-phase extraction of antidepressants from urine samples

• Published in: Mikrochimica acta (1966) 2018-02, Vol.185 (2), p.127-7, Article 127
• Main Authors: Fresco-Cala, Beatriz, Mompó-Roselló, Óscar, Simó-Alfonso, Ernesto F., Cárdenas, Soledad, Herrero-Martínez, José Manuel
• Format: Article
• Language: English
• Subjects: Adsorption; Analytical Chemistry; Antidepressants; Antidepressants, Tricyclic; Carbon nanotubes; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Ethylene; Methods; Microengineering; Multi wall carbon nanotubes; Nanochemistry; Nanotechnology; Nanotubes; Original Paper; Polypropylene; Solids; Tips; Urine
• ISSN: 0026-3672; 1436-5073
• DOI: 10.1007/s00604-017-2659-4

This work evaluates the potential of methacrylate monoliths with multi-walled carbon nanotubes incorporated into the polymeric network for the extraction of antidepressants from human urine. The method is based on a micropipette solid-phase extraction tip containing a hybrid monolithic material covalently attached to the polypropylene housing. A polymer layer made from poly(ethylene dimethacrylate) was bound to the inner surface of a polypropylene tip via UV grafting. The preparation of the monolith and the microextraction steps were optimized in terms of adsorption capacity. Limits of detection ranged from 9 to 15 μg·L −1 . The average precision of the method varied between 3 and 5% (intra-tips), and from 4 to 14% (inter-tips). The accuracy of the method was evaluated through a recovery study by using spiked samples. Graphical abstract Hybrid polymer monoliths containing multi-walled carbon nanotubes (MWCNTs) were prepared in pipette tips by photo-polymerization approach. The extraction devices were used for the extraction of antidepressants in urine samples.