Colorectal carcinoma: Ex vivo evaluation using q‐space imaging; Correlation with histopathologic findings

• Published in: Journal of magnetic resonance imaging 2018-10, Vol.48 (4), p.1059-1068
• Main Authors: Yamada, Ichiro, Hikishima, Keigo, Yoshino, Norio, Sakamoto, Junichiro, Miyasaka, Naoyuki, Yamauchi, Shinichi, Uetake, Hiroyuki, Yasuno, Masamichi, Saida, Yukihisa, Tateishi, Ukihide, Kobayashi, Daisuke, Eishi, Yoshinobu
• Format: Article
• Language: English
• Subjects: colon; Colorectal cancer; Colorectal carcinoma; Correlation coefficient; Correlation coefficients; Diagnostic systems; Diffusion coefficient; diffusion‐weighted imaging; Field of view; Field strength; Kurtosis; Lymph nodes; Magnetic resonance imaging; Medical imaging; Medical prognosis; Metastases; MR imaging; q‐space imaging; rectum; Statistical analysis; Statistical methods; Statistical tests
• ISSN: 1053-1807; 1522-2586
• DOI: 10.1002/jmri.26018

Background Although the prognosis of colorectal carcinoma (CRC) patients depends on the histologic grade (HG) and lymph node metastasis (LNM), accurate preoperative assessment of these prognostic factors is often difficult. Purpose To assess the HG and extent of LNM by q‐space imaging (QSI) for preoperative diagnosis of CRC. Study Type Prospective. Specimen A total of 20 colorectal tissue samples containing adenocarcinomas and resected lymph nodes (LNs). Field Strength/Sequence QSI was performed with a 3T MRI system using a diffusion‐weighted echo‐planar imaging sequence: repetition time, 10,000 msec; echo time, 216 or 210 msec; field of view, 113 × 73.45 mm; matrix, 120 × 78; section thickness, 4 mm; and 11 b values ranging from 0 to 9000 s/mm2. Assessment The mean displacement (MDP; μm), zero‐displacement probability (ZDP; arbitrary unit [a.u.]), kurtosis (K; a.u.), and apparent diffusion coefficient (ADC) were analyzed by two observers and compared with histopathologic findings. Statistical Tests Spearman's rank correlation coefficient, Mann–Whitney U‐test, and ROC curve analyses. Results For all 20 carcinomas, the MDP, ZDP, K, and ADC were 8.87 ± 0.37 μm, 82.0 ± 6.2 a.u., 74.3 ± 3.0 a.u., and 0.219 ± 0.040 × 10−3 mm2/s, respectively. The MDP (r = –0.768; P