Functional visceral fat activity evaluated by preoperative F‐18 FDG PET/CT predicts regional lymph node metastasis in differentiated thyroid cancer

Summary Objective We investigated the predictive role of functional visceral fat activity evaluated by preoperative F‐18 FDG PET/CT for regional lymph node metastasis in patients with differentiated thyroid cancer. Design and patients Fifty‐eight patients with newly diagnosed differentiated thyroid...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2018-06, Vol.88 (6), p.963-968
Main Authors: Pahk, Kisoo, Choi, Sunju, Kim, Sungeun
Format: Article
Language:English
Subjects:
Biopsy
differentiated thyroid cancer
F‐18 FDG PET/CT
Lymph nodes
Lymphatic system
Metastases
Metastasis
PET/CT
Positron emission tomography
Surgery
Thyroid cancer
visceral fat
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Summary:Summary Objective We investigated the predictive role of functional visceral fat activity evaluated by preoperative F‐18 FDG PET/CT for regional lymph node metastasis in patients with differentiated thyroid cancer. Design and patients Fifty‐eight patients with newly diagnosed differentiated thyroid cancer were enrolled in this study, retrospectively (men 14; women 44; age 53 ± 14.5). They all received preoperative F‐18 FDG PET/CT and surgery. Functional visceral fat activity was defined as maximum standardized uptake value (SUVmax) of visceral fat divided by SUVmax of subcutaneous fat (V/S ratio). Pathology results were confirmed through the surgical specimens. Results The patients with regional lymph node metastasis showed higher functional visceral fat activity (V/S ratio) than the patients without regional lymph node metastasis (2.12 ± 0.6 vs 1.62 ± 0.34, P = .001). V/S ratio of 1.78 was suggested as an optimal cut‐off value for predicting regional lymph node metastasis (sensitivity; 70.3%, specificity; 83.3%, area under the curve; 0.778, P 
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.13604