Anti‐Muellerian hormone concentration in bitches with histopathologically diagnosed ovarian tumours and cysts

• Published in: Reproduction in domestic animals 2018-06, Vol.53 (3), p.784-792
• Main Authors: Walter, B, Coelfen, A, Jäger, K, Reese, S, Meyer‐Lindenberg, A, Aupperle‐Lellbach, H
• Format: Article
• Language: English
• Subjects: Cysts; Neoplasms; Ovaries; Sarcoma; Surgery; Tumors
• ISSN: 0936-6768; 1439-0531
• DOI: 10.1111/rda.13171

Contents Increased concentrations of Anti‐Muellerian hormone (AMH) can indicate a granulosa cell tumour as shown in women, mares and cows. To investigate AMH to differentiate canine granulosa cell tumour from other ovarian pathologies, we evaluated the ovaries of 63 bitches. Blood serum samples were collected before surgery for AMH analysis. Ovaries were submitted for histopathological examination. Fourteen bitches showed normal ovaries. These bitches had AMH values between 0.12 and 0.99 ng/ml. In 20 bitches ovarian cysts i.e., follicular cysts (n = 8), corpora lutea cysts (n = 7), subsurface cysts (n = 5) were diagnosed. These dogs had AMH values of 0.11–2.09 ng/ml. Bitches with small luteinized follicular cysts had slightly higher AMH values than those without ovarian alteration. In 29 cases ovarian neoplasms i.e., granulosa cell tumour (n = 9), epithelial tumours (n = 16), dysgerminomas (n = 3) and one sarcoma were identified. Anti‐Muellerian hormone values of bitches with an ovarian neoplasm except granulosa cell tumour ranged from 0.18 to 1.18 ng/ml. The AMH values of bitches with granulosa cell tumour ranged from 1.12 to ≤23 ng/ml and were significantly higher (p