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The association of IL-33 and Foxp3 gene polymorphisms with recurrent pregnancy loss in Egyptian women
•Foxp3 rs2232365 was associated with increased risk for RPL.•IL-33 (rs1929992) wasn't associated with increased risk for RPL.•Foxp3 levels were reduced in women with RPL.•IL-33 levels were reduced in women with RPL. Deregulated immunity is one of the most important factors implicated in recurre...
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Published in: | Cytokine (Philadelphia, Pa.) Pa.), 2018-08, Vol.108, p.115-119 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | •Foxp3 rs2232365 was associated with increased risk for RPL.•IL-33 (rs1929992) wasn't associated with increased risk for RPL.•Foxp3 levels were reduced in women with RPL.•IL-33 levels were reduced in women with RPL.
Deregulated immunity is one of the most important factors implicated in recurrent pregnancy loss (RPL). The possible role of interleukin-33 (IL-33) and forkhead/winged helix transcription factor (Foxp3) in RPL have not been fully investigated. We aimed to evaluate IL-33 rs1929992 and Foxp3 rs2232365 single nucleotide polymorphisms (SNPs) and their serum levels in Egyptian RPL females.
Blood samples were collected from 142 RPL patients and 123 women as healthy controls. IL-33 rs1929992 SNP was determined by polymerase chain reaction restriction fragment length polymorphism and Foxp3 rs2232365 SNP was determined using allele specific polymerase chain reaction. The serum IL-33 and Foxp3 levels were measured by enzyme linked immunosorbent assay.
Foxp3 rs2232365 SNP showed statistically significant association with RPL. The risk of RPL was significantly higher in women carrying Foxp3 G allele than those carrying A allele. Lower serum levels of Foxp3 and IL-33 were observed in RPL patients than controls (P |
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ISSN: | 1043-4666 1096-0023 |
DOI: | 10.1016/j.cyto.2018.03.025 |