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Locoregional extension and patterns of failure for nasopharyngeal carcinoma with intracranial extension
•NPC with intracranial extension spreads follow an orderly pattern.•Patterns of failure for NPC with intracranial extension after IMRT were analyzed.•Clinical target volume reduction may be feasible for selected patients. To evaluate the locoregional extension and patterns of failure for nasopharyng...
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| Published in: | Oral oncology 2018-04, Vol.79, p.27-32 |
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| Main Authors: | , , , , , , , , , , |
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| container_end_page | 32 |
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| container_title | Oral oncology |
| container_volume | 79 |
| creator | Cao, Caineng Jiang, Feng Jin, Qifeng Jin, Ting Huang, Shuang Hu, Qiaoying Chen, Yuanyuan Piao, Yongfeng Hua, Yonghong Feng, Xinglai Chen, Xiaozhong |
| description | •NPC with intracranial extension spreads follow an orderly pattern.•Patterns of failure for NPC with intracranial extension after IMRT were analyzed.•Clinical target volume reduction may be feasible for selected patients.
To evaluate the locoregional extension and patterns of failure for nasopharyngeal carcinoma (NPC) with intracranial extension to improve clinical target volume (CTV) delineation.
A total of 205 NPC patients with intracranial extension by magnetic resonance imaging (MRI) were retrospectively reviewed.
According to the cumulative incidence rates of tumor invasion, we initially classified anatomic sites surrounding the nasopharynx into three risk grades: high risk (≥35%), medium risk (≥10–35%), and low risk ( |
| doi_str_mv | 10.1016/j.oraloncology.2018.02.004 |
| format | article |
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To evaluate the locoregional extension and patterns of failure for nasopharyngeal carcinoma (NPC) with intracranial extension to improve clinical target volume (CTV) delineation.
A total of 205 NPC patients with intracranial extension by magnetic resonance imaging (MRI) were retrospectively reviewed.
According to the cumulative incidence rates of tumor invasion, we initially classified anatomic sites surrounding the nasopharynx into three risk grades: high risk (≥35%), medium risk (≥10–35%), and low risk (<10%). It was concluded that the anatomic sites at high risk of tumor invasion were the middle/posterior skull base and the anatomic sites adjacent to the nasopharynx. The rate of lymph node (LN) metastasis was 90.2% (185/205). Retropharyngeal region (RP) and level IIb were the most frequently involved regions. Skip metastasis occurred in only 1.6% (3/185). At their last follow-up visit, 53 patients (25.9%) had developed treatment failure. Of the 18 local failures, 12 were considered in-field failure; the other 5 were marginal; one of the patients had outside-field failure. Among the 5 patients with marginal failures, 4 occurred mainly intracranially, and 1 occurred in the floor and the left lateral wall of the nasopharynx. Of the 11 regional failures, 10 were considered in-field failures and most of them (8/10) occurred in the unilateral upper neck.
For NPC with intracranial extension, primary disease and regional LN spread follow an orderly pattern and LN skipping was unusual. Clinical target volume reduction may be feasible for selected patients.</description><identifier>ISSN: 1368-8375</identifier><identifier>EISSN: 1879-0593</identifier><identifier>DOI: 10.1016/j.oraloncology.2018.02.004</identifier><identifier>PMID: 29598947</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Clinical target volume ; Female ; Humans ; Local extension ; Lymph node spread ; Lymphatic Metastasis ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Nasopharyngeal carcinoma ; Nasopharyngeal Carcinoma - pathology ; Nasopharyngeal Carcinoma - radiotherapy ; Nasopharyngeal Neoplasms - diagnostic imaging ; Nasopharyngeal Neoplasms - pathology ; Nasopharyngeal Neoplasms - radiotherapy ; Prognosis ; Radiotherapy, Intensity-Modulated ; Skull - pathology ; Survival Analysis ; Young Adult</subject><ispartof>Oral oncology, 2018-04, Vol.79, p.27-32</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-bd6c80158725949fbf7fded96a2feb8a9bd851e1c613ff9529c1a3be0f7717333</citedby><cites>FETCH-LOGICAL-c380t-bd6c80158725949fbf7fded96a2feb8a9bd851e1c613ff9529c1a3be0f7717333</cites><orcidid>0000-0003-1306-601X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29598947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cao, Caineng</creatorcontrib><creatorcontrib>Jiang, Feng</creatorcontrib><creatorcontrib>Jin, Qifeng</creatorcontrib><creatorcontrib>Jin, Ting</creatorcontrib><creatorcontrib>Huang, Shuang</creatorcontrib><creatorcontrib>Hu, Qiaoying</creatorcontrib><creatorcontrib>Chen, Yuanyuan</creatorcontrib><creatorcontrib>Piao, Yongfeng</creatorcontrib><creatorcontrib>Hua, Yonghong</creatorcontrib><creatorcontrib>Feng, Xinglai</creatorcontrib><creatorcontrib>Chen, Xiaozhong</creatorcontrib><title>Locoregional extension and patterns of failure for nasopharyngeal carcinoma with intracranial extension</title><title>Oral oncology</title><addtitle>Oral Oncol</addtitle><description>•NPC with intracranial extension spreads follow an orderly pattern.•Patterns of failure for NPC with intracranial extension after IMRT were analyzed.•Clinical target volume reduction may be feasible for selected patients.
To evaluate the locoregional extension and patterns of failure for nasopharyngeal carcinoma (NPC) with intracranial extension to improve clinical target volume (CTV) delineation.
A total of 205 NPC patients with intracranial extension by magnetic resonance imaging (MRI) were retrospectively reviewed.
According to the cumulative incidence rates of tumor invasion, we initially classified anatomic sites surrounding the nasopharynx into three risk grades: high risk (≥35%), medium risk (≥10–35%), and low risk (<10%). It was concluded that the anatomic sites at high risk of tumor invasion were the middle/posterior skull base and the anatomic sites adjacent to the nasopharynx. The rate of lymph node (LN) metastasis was 90.2% (185/205). Retropharyngeal region (RP) and level IIb were the most frequently involved regions. Skip metastasis occurred in only 1.6% (3/185). At their last follow-up visit, 53 patients (25.9%) had developed treatment failure. Of the 18 local failures, 12 were considered in-field failure; the other 5 were marginal; one of the patients had outside-field failure. Among the 5 patients with marginal failures, 4 occurred mainly intracranially, and 1 occurred in the floor and the left lateral wall of the nasopharynx. Of the 11 regional failures, 10 were considered in-field failures and most of them (8/10) occurred in the unilateral upper neck.
For NPC with intracranial extension, primary disease and regional LN spread follow an orderly pattern and LN skipping was unusual. Clinical target volume reduction may be feasible for selected patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Clinical target volume</subject><subject>Female</subject><subject>Humans</subject><subject>Local extension</subject><subject>Lymph node spread</subject><subject>Lymphatic Metastasis</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nasopharyngeal carcinoma</subject><subject>Nasopharyngeal Carcinoma - pathology</subject><subject>Nasopharyngeal Carcinoma - radiotherapy</subject><subject>Nasopharyngeal Neoplasms - diagnostic imaging</subject><subject>Nasopharyngeal Neoplasms - pathology</subject><subject>Nasopharyngeal Neoplasms - radiotherapy</subject><subject>Prognosis</subject><subject>Radiotherapy, Intensity-Modulated</subject><subject>Skull - pathology</subject><subject>Survival Analysis</subject><subject>Young Adult</subject><issn>1368-8375</issn><issn>1879-0593</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqNkE9vFCEYxomxsbX6FQzx5GXGFxgG8GZqqyabeKlnwjAvWzazsMKs2m8vzVbTo6f3OTx_8v4IecugZ8DG97s-F7fk5POSt_c9B6Z74D3A8IxcMK1MB9KI502LUXdaKHlOXta6AwDJJLwg59xIo82gLsh2k30uuI05uYXi7xVTbZq6NNODW1csqdIcaHBxORakIReaXM2HO1fu0xZbyLviY8p7R3_F9Y7GtBbni0vxaeErchbcUvH1470k32-ub6--dJtvn79efdx0XmhYu2kevQYmteLSDCZMQYUZZzM6HnDSzkyzlgyZH5kIwUhuPHNiQghKMSWEuCTvTr2Hkn8csa52H6vHZXEJ87FaDhwGM3AFzfrhZPUl11ow2EOJ-_aWZWAfQNudfQraPoC2wG0D3cJvHneO0x7nf9G_ZJvh08mA7dufEYutPmLyOMeCfrVzjv-z8we3nJmh</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Cao, Caineng</creator><creator>Jiang, Feng</creator><creator>Jin, Qifeng</creator><creator>Jin, Ting</creator><creator>Huang, Shuang</creator><creator>Hu, Qiaoying</creator><creator>Chen, Yuanyuan</creator><creator>Piao, Yongfeng</creator><creator>Hua, Yonghong</creator><creator>Feng, Xinglai</creator><creator>Chen, Xiaozhong</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1306-601X</orcidid></search><sort><creationdate>201804</creationdate><title>Locoregional extension and patterns of failure for nasopharyngeal carcinoma with intracranial extension</title><author>Cao, Caineng ; Jiang, Feng ; Jin, Qifeng ; Jin, Ting ; Huang, Shuang ; Hu, Qiaoying ; Chen, Yuanyuan ; Piao, Yongfeng ; Hua, Yonghong ; Feng, Xinglai ; Chen, Xiaozhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-bd6c80158725949fbf7fded96a2feb8a9bd851e1c613ff9529c1a3be0f7717333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Clinical target volume</topic><topic>Female</topic><topic>Humans</topic><topic>Local extension</topic><topic>Lymph node spread</topic><topic>Lymphatic Metastasis</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nasopharyngeal carcinoma</topic><topic>Nasopharyngeal Carcinoma - pathology</topic><topic>Nasopharyngeal Carcinoma - radiotherapy</topic><topic>Nasopharyngeal Neoplasms - diagnostic imaging</topic><topic>Nasopharyngeal Neoplasms - pathology</topic><topic>Nasopharyngeal Neoplasms - radiotherapy</topic><topic>Prognosis</topic><topic>Radiotherapy, Intensity-Modulated</topic><topic>Skull - pathology</topic><topic>Survival Analysis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cao, Caineng</creatorcontrib><creatorcontrib>Jiang, Feng</creatorcontrib><creatorcontrib>Jin, Qifeng</creatorcontrib><creatorcontrib>Jin, Ting</creatorcontrib><creatorcontrib>Huang, Shuang</creatorcontrib><creatorcontrib>Hu, Qiaoying</creatorcontrib><creatorcontrib>Chen, Yuanyuan</creatorcontrib><creatorcontrib>Piao, Yongfeng</creatorcontrib><creatorcontrib>Hua, Yonghong</creatorcontrib><creatorcontrib>Feng, Xinglai</creatorcontrib><creatorcontrib>Chen, Xiaozhong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cao, Caineng</au><au>Jiang, Feng</au><au>Jin, Qifeng</au><au>Jin, Ting</au><au>Huang, Shuang</au><au>Hu, Qiaoying</au><au>Chen, Yuanyuan</au><au>Piao, Yongfeng</au><au>Hua, Yonghong</au><au>Feng, Xinglai</au><au>Chen, Xiaozhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Locoregional extension and patterns of failure for nasopharyngeal carcinoma with intracranial extension</atitle><jtitle>Oral oncology</jtitle><addtitle>Oral Oncol</addtitle><date>2018-04</date><risdate>2018</risdate><volume>79</volume><spage>27</spage><epage>32</epage><pages>27-32</pages><issn>1368-8375</issn><eissn>1879-0593</eissn><abstract>•NPC with intracranial extension spreads follow an orderly pattern.•Patterns of failure for NPC with intracranial extension after IMRT were analyzed.•Clinical target volume reduction may be feasible for selected patients.
To evaluate the locoregional extension and patterns of failure for nasopharyngeal carcinoma (NPC) with intracranial extension to improve clinical target volume (CTV) delineation.
A total of 205 NPC patients with intracranial extension by magnetic resonance imaging (MRI) were retrospectively reviewed.
According to the cumulative incidence rates of tumor invasion, we initially classified anatomic sites surrounding the nasopharynx into three risk grades: high risk (≥35%), medium risk (≥10–35%), and low risk (<10%). It was concluded that the anatomic sites at high risk of tumor invasion were the middle/posterior skull base and the anatomic sites adjacent to the nasopharynx. The rate of lymph node (LN) metastasis was 90.2% (185/205). Retropharyngeal region (RP) and level IIb were the most frequently involved regions. Skip metastasis occurred in only 1.6% (3/185). At their last follow-up visit, 53 patients (25.9%) had developed treatment failure. Of the 18 local failures, 12 were considered in-field failure; the other 5 were marginal; one of the patients had outside-field failure. Among the 5 patients with marginal failures, 4 occurred mainly intracranially, and 1 occurred in the floor and the left lateral wall of the nasopharynx. Of the 11 regional failures, 10 were considered in-field failures and most of them (8/10) occurred in the unilateral upper neck.
For NPC with intracranial extension, primary disease and regional LN spread follow an orderly pattern and LN skipping was unusual. Clinical target volume reduction may be feasible for selected patients.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>29598947</pmid><doi>10.1016/j.oraloncology.2018.02.004</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-1306-601X</orcidid></addata></record> |
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| ispartof | Oral oncology, 2018-04, Vol.79, p.27-32 |
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| subjects | Adolescent Adult Aged Clinical target volume Female Humans Local extension Lymph node spread Lymphatic Metastasis Magnetic Resonance Imaging Male Middle Aged Nasopharyngeal carcinoma Nasopharyngeal Carcinoma - pathology Nasopharyngeal Carcinoma - radiotherapy Nasopharyngeal Neoplasms - diagnostic imaging Nasopharyngeal Neoplasms - pathology Nasopharyngeal Neoplasms - radiotherapy Prognosis Radiotherapy, Intensity-Modulated Skull - pathology Survival Analysis Young Adult |
| title | Locoregional extension and patterns of failure for nasopharyngeal carcinoma with intracranial extension |
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