Effects of gadolinium‐based MRI contrast agents on liver tissue

Background MRI with contrast is often used clinically. However, recent studies have reported a high accumulation of gadolinium‐based contrast agents (GBCAs) in kidney, liver, and spleen tissues in several mouse models. Purpose To compare the effects on liver tissue of gadolinium‐based MRI contrast a...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2018-11, Vol.48 (5), p.1367-1374
Main Authors: Mercantepe, Tolga, Tümkaya, Levent, Çeliker, Fatma Beyazal, Topal Suzan, Zehra, Çinar, Seda, Akyildiz, Kerimali, Mercantepe, Filiz, Yilmaz, Adnan
Format: Article
Language:English
Subjects:
Acids
Animal models
Antioxidants
Apoptosis
Biochemical tests
Caspase
Contrast agents
Correlation analysis
Field strength
gadodiamide
Gadolinium
gadoteric acid
Hepatocytes
Kidneys
Kruskal-Wallis test
Liver
Magnetic resonance imaging
Necrosis
Oxidative stress
rat
Rats
Spleen
Statistical analysis
Statistical tests
Tissues
Variance analysis
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Summary:Background MRI with contrast is often used clinically. However, recent studies have reported a high accumulation of gadolinium‐based contrast agents (GBCAs) in kidney, liver, and spleen tissues in several mouse models. Purpose To compare the effects on liver tissue of gadolinium‐based MRI contrast agents in the light of biochemical and histopathological evaluation. Study Type Institutional Review Board (IRB)‐approved controlled longitudinal study. Animal Model In all, 32 male Sprague–Dawley rats were divided into a healthy control group subjected to no procedure (Group 1), a sham group (Group 2), a gadodiamide group (Group 3), and a gadoteric acid group (Group 4). Field Strength/Sequence Not applicable. Assessment Liver tissues removed at the end of the fifth week and evaluated pathologically (scored Knodell's histological activity index [HAI] method by two histopathologists) immunohistochemical (caspase‐3 and biochemical tests (AST, ALT, TAS, TOS, and OSI method by Erel et al) were obtained. Statistical Tests Differences between groups were analyzed using the nonparametric Kruskal–Wallis test followed by the Tamhane test, and one‐way analysis of variance (ANOVA) followed by Turkey's HSD test. Results An increase was observed in histological activity scores in sections from rats administered gadodiamide and gadoteric acid, and in caspase‐3, AST and ALT values (P 
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.26031