Orally administered Lactobacillus paracasei KW3110 induces in vivo IL-12 production

Lactic acid bacteria (LAB) are popularly used as probiotics, and some strains of LAB have anti-allergic functions in vivo. Although in vitro studies show that LAB modulate the T helper type (Th) 1/Th2 balance and inhibit IgE secretion by inducing IL-12, it is not known how LAB regulates allergies in...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2009-07, Vol.73 (7), p.1561-1565
Main Authors: Ichikawa, S.(Kirin Holdings Co. Ltd., Yokohama (Japan)), Miyake, M, Fujii, R, Konishi, Y
Format: Article
Language:English
Subjects:
ADMINISTRACION ORAL
ADMINISTRATION ORALE
Administration, Oral
Animals
BACTERIAS ACIDOLACTICAS
BACTERIE LACTIQUE
Biological and medical sciences
Fluorescein-5-isothiocyanate - metabolism
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
HYPERSENSITIVITY
IL-12
IMMUNOGLOBULINE
IMMUNOGLOBULINS
INMUNOGLOBULINA
Interleukin-12 - biosynthesis
Interleukin-12 - blood
Interleukin-12 - immunology
Interleukin-12 - secretion
INTERLEUKINE
INTERLEUKINS
INTERLEUQUINAS
LACTIC ACID BACTERIA
Lactobacillus - immunology
Lactobacillus - metabolism
Lactobacillus paracasei
Lymph Nodes - metabolism
LYMPHATIC SYSTEM
MICE
Mice, Inbred BALB C
ORAL ADMINISTRATION
Peyer's patch
Peyer's Patches - metabolism
PROBIOTICOS
PROBIOTICS
Probiotics - administration & dosage
Probiotics - metabolism
PROBIOTIQUE
RATON
REACCIONES ALERGICAS
REACTION ALLERGIQUE
SISTEMA LINFATICO
SOURIS
Staining and Labeling
SYSTEME LYMPHATIQUE
Th1 Cells - immunology
Time Factors
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Summary:Lactic acid bacteria (LAB) are popularly used as probiotics, and some strains of LAB have anti-allergic functions in vivo. Although in vitro studies show that LAB modulate the T helper type (Th) 1/Th2 balance and inhibit IgE secretion by inducing IL-12, it is not known how LAB regulates allergies in vivo. In this study, we evaluated in vivo IL-12 production after oral administration of Lactobacillus paracasei KW3110, a strain reported to improve allergies, to mice. Orally administered KW3110 interacted with CD11b positive cells and induced IL-12 mRNA expression at Peyer's patch. In addition, blood IL-12 levels increased transiently 10 h after administration of KW3110. Based on these results, we found that oral administration of KW3110 induces IL-12 in vivo. Our findings should contribute to understanding of the in vivo function of LAB.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.90058