Granulomatous rosacea and Crohn's disease in a patient homozygous for the Crohn-associated NOD2/CARD15 polymorphism R702W

:  NOD2/CARD15 belongs to the N‐terminal caspase recruitment domain family of proteins involved in regulating NF‐kB activation in response to inflammatory stimuli transduced through Toll‐like receptors. Mutations and polymorphisms in the NOD2/CARD15 gene reduce antibacterial responses and are associ...

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Bibliographic Details
Published in:Experimental dermatology 2008-12, Vol.17 (12), p.1057-1058
Main Authors: Van Steensel, M. A. M., Badeloe, S., Winnepenninckx, V., Vreeburg, M., Steijlen, P. M., Van Geel, M.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child
Crohn
Crohn Disease - complications
Crohn Disease - genetics
Dermatology
Female
Gastroenterology. Liver. Pancreas. Abdomen
granulomatous
Homozygote
Humans
Medical sciences
Mutation, Missense
Nod2 Signaling Adaptor Protein - genetics
NOD2/CARD15
Other diseases. Semiology
polymorphism
Polymorphism, Single Nucleotide
rosacea
Rosacea - complications
Rosacea - genetics
Skin involvement in other diseases. Miscellaneous. General aspects
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary::  NOD2/CARD15 belongs to the N‐terminal caspase recruitment domain family of proteins involved in regulating NF‐kB activation in response to inflammatory stimuli transduced through Toll‐like receptors. Mutations and polymorphisms in the NOD2/CARD15 gene reduce antibacterial responses and are associated with granulomatous inflammatory conditions such as Blau syndrome and early‐onset sarcoidosis. The polymorphism R702W (arginine to tryptophan) is strongly associated with susceptibility to Crohn’s disease in Caucasian populations. Skin abnormalities (other than cutaneous manifestations of Crohn’s disease) have not been previously associated with R702W. We report on a female patient homozygous for R702W who developed granulomatous rosacea at the age of 12 years old. From the occurrence in the context of Crohn associated with R702W, we speculate that granulomatous rosacea may be an entity distinct from other forms of rosacea, which are associated with increased production of antibacterial proteins such as cathelicidin.
ISSN:0906-6705
1600-0625
DOI:10.1111/j.1600-0625.2008.00753.x