Metastasis in patients with hepatocellular carcinoma: Prevalence, determinants, prognostic impact and ability to improve the Barcelona Clinic Liver Cancer system

Background & Aim Patients with hepatocellular carcinoma and metastasis are classified as advanced or terminal stage by the Barcelona Clinic Liver Cancer system. This study investigates the prevalence, determinants, and prognostic effect of metastasis and its ability to improve the Barcelona Clin...

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Bibliographic Details
Published in:Liver international 2018-10, Vol.38 (10), p.1803-1811
Main Authors: Hsu, Chia‐Yang, Liu, Po‐Hong, Ho, Shu‐Yein, Huang, Yi‐Hsiang, Lee, Yun‐Hsuan, Lee, Rheun‐Chuan, Nagaria, Teddy S., Hou, Ming‐Chih, Huo, Teh‐Ia
Format: Article
Language:English
Subjects:
Alcoholism
Barcelona Clinic Liver Cancer
Cancer
Criteria
Drug abuse
Hepatitis
Hepatitis B
Hepatocellular carcinoma
Liver
Liver cancer
Metastases
Metastasis
Patients
staging system
Survival
Tumors
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Summary:Background & Aim Patients with hepatocellular carcinoma and metastasis are classified as advanced or terminal stage by the Barcelona Clinic Liver Cancer system. This study investigates the prevalence, determinants, and prognostic effect of metastasis and its ability to improve the Barcelona Clinic Liver Cancer system. Methods A total of 3414 patients were enrolled. The Kaplan‐Meier and Cox regression methods were used to determine survival predictors. Akaike information criterion was used to compare the prognostic performance of staging systems. Results There were 357 (10%) patients having extrahepatic metastasis at the time of diagnosis. Metastases were associated with old age, alcoholism, hepatitis B, poorer liver function, higher α‐foetoprotein level and larger tumour burden (all P 
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.13748