The Potential Role of PTPN-22 C1858T Gene Polymorphism in the Pathogenesis of Type 1 Diabetes in Saudi Population

Background: Recent investigations have reported an association between protein tyrosine phosphatase non-receptor type-22 (PTPN-22) gene polymorphism and susceptibility to the development of type 1 diabetes (T1D) in some populations and not in others. In this study, we aimed to investigate the associ...

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Bibliographic Details
Published in:Immunological investigations 2018-07, Vol.47 (5), p.521-533
Main Authors: Alswat, Khaled A., Nasr, Amre, Al Dubayee, Mohammed S., Talaat, Iman M., Alsulaimani, Adnan A., Mohamed, Imad A.A., Allam, Gamal
Format: Article
Language:English
Subjects:
PTPN-22 gene polymorphism
Saudi population
Type 1 Diabetes
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Summary:Background: Recent investigations have reported an association between protein tyrosine phosphatase non-receptor type-22 (PTPN-22) gene polymorphism and susceptibility to the development of type 1 diabetes (T1D) in some populations and not in others. In this study, we aimed to investigate the association of PTPN-22 C1858T polymorphism with T1D in Saudi children. Methods: A cohort of 372 type 1 diabetic children and 372 diabetes-free subjects was enrolled in the current investigation. The PTPN-22 C1858T polymorphism was identified using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: Our data showed that the frequency of CT and TT genotypes of PTPN-22 C1858T was higher in T1D children (17.7% and 4.3%, respectively) compared to healthy controls (4.8% and 1.6%, respectively), and both genotypes were statistically associated with T1D patients (OR = 4.4, 95% CI: 2.55-7.58, p 
ISSN:0882-0139
1532-4311
DOI:10.1080/08820139.2018.1458109