Associations between genetic polymorphisms of membrane transporter genes and prognosis after chemotherapy: meta-analysis and finding from Seoul Breast Cancer Study (SEBCS)

Membrane transporters can be major determinants of the pharmacokinetic profiles of anticancer drugs. The associations between genetic variations of ATP-binding cassette (ABC) and solute carrier (SLC) genes and cancer survival were investigated through a meta-analysis and an association study in the...

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Bibliographic Details
Published in:The pharmacogenomics journal 2018-09, Vol.18 (5), p.633-645
Main Authors: Kim, Ji-Eun, Choi, Jaesung, Park, JooYong, Park, Chulbum, Lee, Se Mi, Park, Seong Eun, Song, Nan, Chung, Seokang, Sung, Hyuna, Han, Wonshik, Lee, Jong Won, Park, Sue K., Kim, Mi Kyung, Noh, Dong-Young, Yoo, Keun-Young, Kang, Daehee, Choi, Ji-Yeob
Format: Article
Language:English
Subjects:
45/43
631/208/205
631/67/69
692/53/2423
Antineoplastic Agents - therapeutic use
Antineoplastic drugs
Antitumor agents
Biomedical and Life Sciences
Biomedicine
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - genetics
Chemotherapy
Female
Gene Expression
Genetic diversity
Human Genetics
Humans
Medical prognosis
Membrane Transport Proteins - genetics
Meta-analysis
Oncology
Pharmacotherapy
Polymorphism, Single Nucleotide - genetics
Prognosis
Progression-Free Survival
Psychopharmacology
Seoul
Single-nucleotide polymorphism
Survival
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Summary:Membrane transporters can be major determinants of the pharmacokinetic profiles of anticancer drugs. The associations between genetic variations of ATP-binding cassette (ABC) and solute carrier (SLC) genes and cancer survival were investigated through a meta-analysis and an association study in the Seoul Breast Cancer Study (SEBCS). Including the SEBCS, the meta-analysis was conducted among 38 studies of genetic variations of transporters on various cancer survivors. The population of SEBCS consisted of 1338 breast cancer patients who had been treated with adjuvant chemotherapy. A total of 7750 SNPs were selected from 453 ABC and/or SLC genes typed by an Affymetrix 6.0 chip. ABCB1 rs1045642 was associated with poor progression-free survival in a meta-analysis (HR = 1.33, 95% CI: 1.07–1.64). ABCB1 , SLC8A1 , and SLC12A8 were associated with breast cancer survival in SEBCS ( P gene  
ISSN:1470-269X
1473-1150
DOI:10.1038/s41397-018-0016-6