Opto-acousto-fluidic microscopy for three-dimensional label-free detection of droplets and cells in microchannels

This paper reports a novel method, opto-acousto-fluidic microscopy, for label-free detection of droplets and cells in microfluidic networks. Leveraging the optoacoustic effect, the microscopic system possesses capabilities of visualizing flowing droplets, analyzing droplet contents, and detecting ce...

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Bibliographic Details
Published in:Lab on a chip 2018-01, Vol.18 (9), p.1292-1297
Main Authors: Song, Chaolong, Jin, Tian, Yan, Ruopeng, Qi, Weizhi, Huang, Tianye, Ding, Huafeng, Tan, Say Hwa, Nguyen, Nam-Trung, Xi, Lei
Format: Article
Language:English
Subjects:
Acoustic absorption
Droplets
Microchannels
Microscopy
Photoacoustic effect
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Summary:This paper reports a novel method, opto-acousto-fluidic microscopy, for label-free detection of droplets and cells in microfluidic networks. Leveraging the optoacoustic effect, the microscopic system possesses capabilities of visualizing flowing droplets, analyzing droplet contents, and detecting cell populations encapsulated in droplets via the sensing of acoustic waves induced by the intrinsic light-absorbance of matter.
ISSN:1473-0197
1473-0189
DOI:10.1039/c8lc00106e