Retrograde Signaling as a Mechanism of Yeast Adaptation to Unfavorable Factors

Mitochondria perform many essential functions in eukaryotic cells. Being the main producers of ATP and the site of many catabolic and anabolic reactions, they participate in intracellular signaling, proliferation, aging, and formation of reactive oxygen species. Mitochondrial dysfunction is the caus...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2018-02, Vol.83 (2), p.98-106
Main Authors: Trendeleva, T. A., Zvyagilskaya, R. A.
Format: Article
Language:English
Subjects:
14-3-3 protein
Autophagy
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism
Biochemistry
Biological research
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Cell death
Cell Nucleus - metabolism
Cellular signal transduction
Drug Resistance, Fungal
Evolutionary adaptation
Genetic aspects
Intracellular signalling
Kinases
Life Sciences
Microbiology
Mitochondria
Mitochondria - genetics
Mitochondria - metabolism
Nuclei
Proteins
Reactive oxygen species
Retrograde transport
Review
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - metabolism
Signal transduction
Signal Transduction - physiology
TOR Serine-Threonine Kinases - metabolism
Transducers
Yeast
Yeasts
Yeasts (Fungi)
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Summary:Mitochondria perform many essential functions in eukaryotic cells. Being the main producers of ATP and the site of many catabolic and anabolic reactions, they participate in intracellular signaling, proliferation, aging, and formation of reactive oxygen species. Mitochondrial dysfunction is the cause of many diseases and even cell death. The functioning of mitochondria in vivo is impossible without interaction with other cellular compartments. Mitochondrial retrograde signaling is a signaling pathway connecting mitochondria and the nucleus. The major signal transducers in the yeast retrograde response are Rtg1p, Rtg2p, and Rtg3p proteins, as well as four additional negative regulatory factors–Mks1p, Lst8p, and two 14-3-3 proteins (Bmh1/2p). In this review, we analyze current information on the retrograde signaling in yeast that is regarded as a stress or homeostatic response mechanism to changes in various metabolic and biosynthetic activities that occur upon mitochondrial dysfunction. We also discuss relations between retrograde signaling and other signaling pathways in the cell.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297918020025