Predictors of surgical outcome and early criteria of remission in acromegaly

Background Transsphenoidal surgery (TSS) is the cornerstone of acromegaly treatment, however there are no robust predictors of surgical outcome and remission can only be defined three months after surgery. Purpose To analyze if biochemical, demographical, radiological, and immunohistochemical charac...

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Bibliographic Details
Published in:Endocrine 2018-06, Vol.60 (3), p.415-422
Main Authors: Antunes, Ximene, Ventura, Nina, Camilo, Gustavo Bittencourt, Wildemberg, Luiz Eduardo, Guasti, Andre, Pereira, Paulo José M., Camacho, Aline Helen Silva, Chimelli, Leila, Niemeyer, Paulo, Gadelha, Mônica R., Kasuki, Leandro
Format: Article
Language:English
Subjects:
Acromegaly
Acromegaly - blood
Acromegaly - surgery
Adenoma - blood
Adenoma - surgery
Adult
Diabetes
Endocrine Surgery
Endocrinology
Female
Human Growth Hormone - blood
Humanities and Social Sciences
Humans
Insulin-like growth factor I
Insulin-Like Growth Factor I - metabolism
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
multidisciplinary
Patients
Pituitary Neoplasms - blood
Pituitary Neoplasms - surgery
Postoperative Period
Prognosis
Remission
Remission Induction
Science
Surgery
Surgical outcomes
Treatment Outcome
Tumors
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Summary:Background Transsphenoidal surgery (TSS) is the cornerstone of acromegaly treatment, however there are no robust predictors of surgical outcome and remission can only be defined three months after surgery. Purpose To analyze if biochemical, demographical, radiological, and immunohistochemical characteristics are predictors of surgical remission and investigate if immediate postoperative GH and IGF-I levels can help defining remission earlier. Methods Consecutive acromegaly patients submitted to TSS between 2013-2016 were evaluated. Remission criteria was defined as normal IGF-I and GH
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-018-1590-8