Synthetic Approaches to Tetracyclic Indolines as Versatile Building Blocks of Diverse Indole Alkaloids

Indole alkaloids bearing the tetracyclic indoline scaffolds of 1H‐pyrrolo[2,3‐d]carbazole have shown fascinating chemical diversity and significant biological activities. The development of efficient synthetic methodologies for such a tetracyclic scaffold remains highly desirable in both synthetic c...

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Bibliographic Details
Published in:Chemistry : a European journal 2018-09, Vol.24 (54), p.14302-14315
Main Authors: Wang, Yanshi, Xie, Fukai, Lin, Bin, Cheng, Maosheng, Liu, Yongxiang
Format: Article
Language:English
Subjects:
Alkaloids
Biodiversity
building blocks
Carbazole
Carbazoles
Chemical reactions
Chemistry
Construction
cyclization
Heterocyclic compounds
Indoles
Organic chemistry
Palladium
Scaffolds
tetracyclic
total synthesis
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Summary:Indole alkaloids bearing the tetracyclic indoline scaffolds of 1H‐pyrrolo[2,3‐d]carbazole have shown fascinating chemical diversity and significant biological activities. The development of efficient synthetic methodologies for such a tetracyclic scaffold remains highly desirable in both synthetic chemistry and medicinal chemistry. This review outlines key strategies for the construction of the tetracyclic indoline scaffolds in total syntheses of many indole alkaloids. The key strategies include nucleophilic additions, Diels–Alder reactions, radical cyclizations, and palladium‐catalyzed coupling reactions. The representative examples and their applications in the total syntheses are described here and discussed in depth. Tetracyclic indolines have acted as versatile building blocks for the syntheses of diverse indole alkaloids through half a century. There is a wide range of synthetic strategies for the common frameworks, which could be classified into nucleophilic additions, Diels–Alder reactions, radical cyclizations, palladium‐catalyzed coupling reactions, etc. The representative examples and their applications in the total syntheses are described here and discussed in depth.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201800775