Diagnostic Test for Incipient Tuberculosis: A Step Forward, Many More to Go

Furthermore, if a test for incipient TB is done before the precipitating event that triggers loss of host control of infection occurs, the result will appear as a false negative. [...]perfect sensitivity also cannot be achieved. Investigators have taken different approaches to develop an incipient T...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2018-05, Vol.197 (9), p.1106-1107
Main Authors: Schumacher, Samuel G, Denkinger, Claudia M
Format: Article
Language:English
Subjects:
Diagnostic tests
Diagnostic Tests, Routine
Disease Progression
HIV
Human immunodeficiency virus
Humans
Infections
Medical diagnosis
Mycobacterium tuberculosis
Patients
Population
Systematic review
Tuberculosis
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Summary:Furthermore, if a test for incipient TB is done before the precipitating event that triggers loss of host control of infection occurs, the result will appear as a false negative. [...]perfect sensitivity also cannot be achieved. Investigators have taken different approaches to develop an incipient TB test, targeting the detection of 1) MTB-specific CD4/CD8-cell IFN-g expression, 2) MTB-specific T-cell surface markers, 3) host protein signatures, and 4) RNA signatures (8-10). [...]the optimal target price per test (
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201803-0469ED