Evaluation of the intracellular activity of drugs against Mycobacterium abscessus using a THP-1 macrophage model

We evaluated the antimicrobial effectiveness against M. abscessus in a THP-1 cell line model. No intracellular activity was observed when using amikacin or imipenem. A bacteriostatic effect was observed for cefoxitin, clarithromycin and azithromycin. Tigecycline showed the best antibacterial effect...

Full description

Saved in:
Bibliographic Details
Published in:Journal of microbiological methods 2018-05, Vol.148, p.29-32
Main Authors: Molina-Torres, Carmen Amelia, Tamez-Peña, Lorena, Castro-Garza, Jorge, Ocampo-Candiani, Jorge, Vera-Cabrera, Lucio
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacokinetics
Anti-Bacterial Agents - pharmacology
Humans
Intracellular activity
Macrophages - metabolism
Macrophages - microbiology
Microbial Viability - drug effects
Models, Biological
Mycobacterium abscessus
Mycobacterium abscessus - drug effects
Mycobacterium abscessus - growth & development
Mycobacterium Infections, Nontuberculous - drug therapy
THP-1 Cells
THP-1 macrophages
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We evaluated the antimicrobial effectiveness against M. abscessus in a THP-1 cell line model. No intracellular activity was observed when using amikacin or imipenem. A bacteriostatic effect was observed for cefoxitin, clarithromycin and azithromycin. Tigecycline showed the best antibacterial effect by decreasing the intracellular growth up to bactericidal level.
ISSN:0167-7012
1872-8359
DOI:10.1016/j.mimet.2018.03.020