Monoclonal antibody against envelope protein from Human Endogenous Retrovirus "W" (MSRV-ENV or Syncytin) inhibits TLR4-initated immunotoxicity cascade in human peripheral blood mononuclear cells and displays therapeutic effects in novel pre-clinical models for Multiple Sclerosis

HERV-W endogenous retroviral family encodes a powerful imunopathogenic envelope protein (MSRV-ENV or Syncytin), causing sequential activation of a pro-inflammatory and autoimmune cascade through initial interaction with Toll-Like receptor 4 (TLR4) on antigen-presenting cells, accompanied by gliotoxi...

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Bibliographic Details
Published in:Journal of neurovirology 2007-01, Vol.13, p.112-112
Main Authors: Perron, H, Sanhadji, K, Bernard, C, Touraine, J-L, Marche, P
Format: Article
Language:English
Subjects:
Human endogenous retrovirus
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Summary:HERV-W endogenous retroviral family encodes a powerful imunopathogenic envelope protein (MSRV-ENV or Syncytin), causing sequential activation of a pro-inflammatory and autoimmune cascade through initial interaction with Toll-Like receptor 4 (TLR4) on antigen-presenting cells, accompanied by gliotoxicity causing blood brain barrier (BBB) breakdown and further triggering superantigen (Sag)-like dysregulation of T-lymphocytes. The specific association of this protein with MS brain lesions post-mortem, as evidenced by independent immunohistological studies, its presence in about 75% of MS sera ex-vivo versus none in healthy controls (Cf. Epidemiology abstract) and its ability to reproduce the "EAE" MS animal model associated with demyelination and autoimmunity, has conducted us to select anti-ENV specific monoclonal antibodies (mAb) capable to block pathogenic effects of this protein in vitro. Further confirmation of therapeutic efficiency on clinical effects in vivo (animal models) was also pursued.
ISSN:1355-0284