Efficient synthesis of 3,3-diheteroaromatic oxindole analogues and their in vitro evaluation for spermicidal potential

Syntheses of 3,3-diheteroaromatic oxindole derivatives has been achieved by coupling indole-2,3-dione (isatin) with differently substituted indoles and pyrrole in presence of I 2 in i-PrOH. The in vitro spermicidal potentials and the mode of spermicidal action of the synthesized analogues were evalu...

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Published in:Bioorganic & medicinal chemistry letters 2009-08, Vol.19 (16), p.4786-4789
Main Authors: Paira, Priyankar, Hazra, Abhijit, Kumar, Shrabanti, Paira, Rupankar, Sahu, Krishnendu B., Naskar, Subhendu, saha, Pritam, Mondal, Shyamal, Maity, Arindam, Banerjee, Sukdeb, Mondal, Nirup B.
Format: Article
Language:English
Subjects:
3,3-diindolyl and dipyrrolyl oxindoles
Animals
Biological and medical sciences
Genital system. Reproduction
Indoles - chemical synthesis
Indoles - chemistry
Indoles - pharmacology
Iodine
Isatin
Medical sciences
Microscopy, Electron, Transmission
Pharmacology. Drug treatments
Rats
Spermatocidal Agents - chemical synthesis
Spermatocidal Agents - chemistry
Spermatocidal Agents - pharmacology
Spermicidal potential
Transmission electron microscopy
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Summary:Syntheses of 3,3-diheteroaromatic oxindole derivatives has been achieved by coupling indole-2,3-dione (isatin) with differently substituted indoles and pyrrole in presence of I 2 in i-PrOH. The in vitro spermicidal potentials and the mode of spermicidal action of the synthesized analogues were evaluated and the derivative, 3,3-bis (5-methoxy-1 H-indol-3-yl) indolin-2-one ( 3d) exhibited most significant activity.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2009.06.049