Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice

[Display omitted] •COS reduced the fasting glucose and improved the dyslipidemia in diabetic mice.•COS maintained the gut integrity by inhibiting p-p38 and increasing AMPK level.•The anti-diabetic effect of COS was associated with the reshape of gut microbiota. The aim of this study is to investigat...

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Bibliographic Details
Published in:Carbohydrate polymers 2018-06, Vol.190, p.77-86
Main Authors: Zheng, Junping, Yuan, Xubing, Cheng, Gong, Jiao, Siming, Feng, Cui, Zhao, Xiaoming, Yin, Heng, Du, Yuguang, Liu, Hongtao
Format: Article
Language:English
Subjects:
Chitosan oligosaccharides
Diabetes
Gut microbiota
Intestinal integrity
Lipogenesis
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Summary:[Display omitted] •COS reduced the fasting glucose and improved the dyslipidemia in diabetic mice.•COS maintained the gut integrity by inhibiting p-p38 and increasing AMPK level.•The anti-diabetic effect of COS was associated with the reshape of gut microbiota. The aim of this study is to investigate the effect of chitosan oligosaccharides (COS) on type 2 diabetes mellitus. Wild type C57BL/6J mice or diabetic db/db mice were treated with vehicle or COS for three months. COS treatment significantly decreased the blood glucose (P 
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2018.02.058