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Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice
[Display omitted] •COS reduced the fasting glucose and improved the dyslipidemia in diabetic mice.•COS maintained the gut integrity by inhibiting p-p38 and increasing AMPK level.•The anti-diabetic effect of COS was associated with the reshape of gut microbiota. The aim of this study is to investigat...
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| Published in: | Carbohydrate polymers 2018-06, Vol.190, p.77-86 |
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| Main Authors: | , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c402t-9d73c9305552f8233a0c729eebb93da7ca14ba7884697e901710e47fc8f9854e3 |
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| cites | cdi_FETCH-LOGICAL-c402t-9d73c9305552f8233a0c729eebb93da7ca14ba7884697e901710e47fc8f9854e3 |
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| container_start_page | 77 |
| container_title | Carbohydrate polymers |
| container_volume | 190 |
| creator | Zheng, Junping Yuan, Xubing Cheng, Gong Jiao, Siming Feng, Cui Zhao, Xiaoming Yin, Heng Du, Yuguang Liu, Hongtao |
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•COS reduced the fasting glucose and improved the dyslipidemia in diabetic mice.•COS maintained the gut integrity by inhibiting p-p38 and increasing AMPK level.•The anti-diabetic effect of COS was associated with the reshape of gut microbiota.
The aim of this study is to investigate the effect of chitosan oligosaccharides (COS) on type 2 diabetes mellitus. Wild type C57BL/6J mice or diabetic db/db mice were treated with vehicle or COS for three months. COS treatment significantly decreased the blood glucose (P |
| doi_str_mv | 10.1016/j.carbpol.2018.02.058 |
| format | article |
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•COS reduced the fasting glucose and improved the dyslipidemia in diabetic mice.•COS maintained the gut integrity by inhibiting p-p38 and increasing AMPK level.•The anti-diabetic effect of COS was associated with the reshape of gut microbiota.
The aim of this study is to investigate the effect of chitosan oligosaccharides (COS) on type 2 diabetes mellitus. Wild type C57BL/6J mice or diabetic db/db mice were treated with vehicle or COS for three months. COS treatment significantly decreased the blood glucose (P < 0.01) and reversed the insulin resistance (P < 0.05) in db/db mice, which was accompanied by suppressing the inflammation mediators (P < 0.05), down-regulating the lipogenesis (P < 0.01) and inhibiting the adipocyte differentiation (P < 0.05) in white adipose tissue. Additionally, COS treatment inhibited the reduction of occludin (P < 0.01) and relieved the gut dysbiosis in diabetic mice by promoting Akkermansia (P < 0.01) and suppressing Helicobacter (P < 0.05). Spearman's correlation analysis indicates that the COS-modulated bacteria are positively correlated with inflammation, hyperglycemia and dyslipidemia. The functional profiling based on the microbiota composition implicated that COS treatment may regulate the metabolic pathways of gut microbiota. In summary, COS treatment remarkably improved the glucose metabolism and reshaped the unbalanced gut microbiota of diabetic mice. Our study provided the evidence for application of COS to the treatment of diabetes mellitus.]]></description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2018.02.058</identifier><identifier>PMID: 29628262</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Blood Glucose - metabolism ; Body Composition - drug effects ; Chitosan - chemistry ; Chitosan oligosaccharides ; Diabetes ; Diabetes Mellitus, Experimental - complications ; Dysbiosis - complications ; Dysbiosis - drug therapy ; Dysbiosis - metabolism ; Dysbiosis - microbiology ; Dyslipidemias - complications ; Enzyme Activation - drug effects ; Gastrointestinal Microbiome - drug effects ; Gut microbiota ; Intestinal integrity ; Lipogenesis ; Male ; Mice ; Mice, Inbred C57BL ; Oligosaccharides - chemistry ; Oligosaccharides - pharmacology ; Oligosaccharides - therapeutic use ; p38 Mitogen-Activated Protein Kinases - metabolism</subject><ispartof>Carbohydrate polymers, 2018-06, Vol.190, p.77-86</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-9d73c9305552f8233a0c729eebb93da7ca14ba7884697e901710e47fc8f9854e3</citedby><cites>FETCH-LOGICAL-c402t-9d73c9305552f8233a0c729eebb93da7ca14ba7884697e901710e47fc8f9854e3</cites><orcidid>0000-0002-9134-572X ; 0000-0002-0190-2917 ; 0000-0001-8193-9236</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29628262$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Junping</creatorcontrib><creatorcontrib>Yuan, Xubing</creatorcontrib><creatorcontrib>Cheng, Gong</creatorcontrib><creatorcontrib>Jiao, Siming</creatorcontrib><creatorcontrib>Feng, Cui</creatorcontrib><creatorcontrib>Zhao, Xiaoming</creatorcontrib><creatorcontrib>Yin, Heng</creatorcontrib><creatorcontrib>Du, Yuguang</creatorcontrib><creatorcontrib>Liu, Hongtao</creatorcontrib><title>Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice</title><title>Carbohydrate polymers</title><addtitle>Carbohydr Polym</addtitle><description><![CDATA[[Display omitted]
•COS reduced the fasting glucose and improved the dyslipidemia in diabetic mice.•COS maintained the gut integrity by inhibiting p-p38 and increasing AMPK level.•The anti-diabetic effect of COS was associated with the reshape of gut microbiota.
The aim of this study is to investigate the effect of chitosan oligosaccharides (COS) on type 2 diabetes mellitus. Wild type C57BL/6J mice or diabetic db/db mice were treated with vehicle or COS for three months. COS treatment significantly decreased the blood glucose (P < 0.01) and reversed the insulin resistance (P < 0.05) in db/db mice, which was accompanied by suppressing the inflammation mediators (P < 0.05), down-regulating the lipogenesis (P < 0.01) and inhibiting the adipocyte differentiation (P < 0.05) in white adipose tissue. Additionally, COS treatment inhibited the reduction of occludin (P < 0.01) and relieved the gut dysbiosis in diabetic mice by promoting Akkermansia (P < 0.01) and suppressing Helicobacter (P < 0.05). Spearman's correlation analysis indicates that the COS-modulated bacteria are positively correlated with inflammation, hyperglycemia and dyslipidemia. The functional profiling based on the microbiota composition implicated that COS treatment may regulate the metabolic pathways of gut microbiota. In summary, COS treatment remarkably improved the glucose metabolism and reshaped the unbalanced gut microbiota of diabetic mice. Our study provided the evidence for application of COS to the treatment of diabetes mellitus.]]></description><subject>Animals</subject><subject>Blood Glucose - metabolism</subject><subject>Body Composition - drug effects</subject><subject>Chitosan - chemistry</subject><subject>Chitosan oligosaccharides</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - complications</subject><subject>Dysbiosis - complications</subject><subject>Dysbiosis - drug therapy</subject><subject>Dysbiosis - metabolism</subject><subject>Dysbiosis - microbiology</subject><subject>Dyslipidemias - complications</subject><subject>Enzyme Activation - drug effects</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Gut microbiota</subject><subject>Intestinal integrity</subject><subject>Lipogenesis</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Oligosaccharides - chemistry</subject><subject>Oligosaccharides - pharmacology</subject><subject>Oligosaccharides - therapeutic use</subject><subject>p38 Mitogen-Activated Protein Kinases - metabolism</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFUU2P0zAQtRArtiz8BJCPXBJsx4ntE0LV8iGtxGU5W_6YtK6SuNhOpb3vD19XLVyZy4xG782bmYfQB0paSujw-dA6k-wxTi0jVLaEtaSXr9CGSqEa2nH-Gm0I5byRAxW36G3OB1JjoOQNumVqYJINbIOet_tQYjYLjlPY1cK5vUnBQ8ZhPqZ4Alz2gH3IZU3WLA5wWPBuWl3MgGcoxlZinrFZPE5wgpSvjKdsQ8wh4zji3VrwHFyKtVXMeYIPxkIJ7tyGd-hmNFOG99d8h35_u3_c_mgefn3_uf360DhOWGmUF51THen7no2SdZ0hTjAFYK3qvBHOUG6NkJIPSoAiVFACXIxOjkr2HLo79Okytx72Z4Vc9Byyg2kyC8Q1a0ZYx0mvpKjQ_gKtS-ecYNTHFGaTnjQl-myAPuirAfpsgCZMVwMq7-NVYrUz-H-svx-vgC8XANRDTwGSzi5A_asPCVzRPob_SLwAMK6cLw</recordid><startdate>20180615</startdate><enddate>20180615</enddate><creator>Zheng, Junping</creator><creator>Yuan, Xubing</creator><creator>Cheng, Gong</creator><creator>Jiao, Siming</creator><creator>Feng, Cui</creator><creator>Zhao, Xiaoming</creator><creator>Yin, Heng</creator><creator>Du, Yuguang</creator><creator>Liu, Hongtao</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9134-572X</orcidid><orcidid>https://orcid.org/0000-0002-0190-2917</orcidid><orcidid>https://orcid.org/0000-0001-8193-9236</orcidid></search><sort><creationdate>20180615</creationdate><title>Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice</title><author>Zheng, Junping ; Yuan, Xubing ; Cheng, Gong ; Jiao, Siming ; Feng, Cui ; Zhao, Xiaoming ; Yin, Heng ; Du, Yuguang ; Liu, Hongtao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-9d73c9305552f8233a0c729eebb93da7ca14ba7884697e901710e47fc8f9854e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Blood Glucose - metabolism</topic><topic>Body Composition - drug effects</topic><topic>Chitosan - chemistry</topic><topic>Chitosan oligosaccharides</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Experimental - complications</topic><topic>Dysbiosis - complications</topic><topic>Dysbiosis - drug therapy</topic><topic>Dysbiosis - metabolism</topic><topic>Dysbiosis - microbiology</topic><topic>Dyslipidemias - complications</topic><topic>Enzyme Activation - drug effects</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Gut microbiota</topic><topic>Intestinal integrity</topic><topic>Lipogenesis</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Oligosaccharides - chemistry</topic><topic>Oligosaccharides - pharmacology</topic><topic>Oligosaccharides - therapeutic use</topic><topic>p38 Mitogen-Activated Protein Kinases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Junping</creatorcontrib><creatorcontrib>Yuan, Xubing</creatorcontrib><creatorcontrib>Cheng, Gong</creatorcontrib><creatorcontrib>Jiao, Siming</creatorcontrib><creatorcontrib>Feng, Cui</creatorcontrib><creatorcontrib>Zhao, Xiaoming</creatorcontrib><creatorcontrib>Yin, Heng</creatorcontrib><creatorcontrib>Du, Yuguang</creatorcontrib><creatorcontrib>Liu, Hongtao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Junping</au><au>Yuan, Xubing</au><au>Cheng, Gong</au><au>Jiao, Siming</au><au>Feng, Cui</au><au>Zhao, Xiaoming</au><au>Yin, Heng</au><au>Du, Yuguang</au><au>Liu, Hongtao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2018-06-15</date><risdate>2018</risdate><volume>190</volume><spage>77</spage><epage>86</epage><pages>77-86</pages><issn>0144-8617</issn><eissn>1879-1344</eissn><abstract><![CDATA[[Display omitted]
•COS reduced the fasting glucose and improved the dyslipidemia in diabetic mice.•COS maintained the gut integrity by inhibiting p-p38 and increasing AMPK level.•The anti-diabetic effect of COS was associated with the reshape of gut microbiota.
The aim of this study is to investigate the effect of chitosan oligosaccharides (COS) on type 2 diabetes mellitus. Wild type C57BL/6J mice or diabetic db/db mice were treated with vehicle or COS for three months. COS treatment significantly decreased the blood glucose (P < 0.01) and reversed the insulin resistance (P < 0.05) in db/db mice, which was accompanied by suppressing the inflammation mediators (P < 0.05), down-regulating the lipogenesis (P < 0.01) and inhibiting the adipocyte differentiation (P < 0.05) in white adipose tissue. Additionally, COS treatment inhibited the reduction of occludin (P < 0.01) and relieved the gut dysbiosis in diabetic mice by promoting Akkermansia (P < 0.01) and suppressing Helicobacter (P < 0.05). Spearman's correlation analysis indicates that the COS-modulated bacteria are positively correlated with inflammation, hyperglycemia and dyslipidemia. The functional profiling based on the microbiota composition implicated that COS treatment may regulate the metabolic pathways of gut microbiota. In summary, COS treatment remarkably improved the glucose metabolism and reshaped the unbalanced gut microbiota of diabetic mice. Our study provided the evidence for application of COS to the treatment of diabetes mellitus.]]></abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>29628262</pmid><doi>10.1016/j.carbpol.2018.02.058</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9134-572X</orcidid><orcidid>https://orcid.org/0000-0002-0190-2917</orcidid><orcidid>https://orcid.org/0000-0001-8193-9236</orcidid></addata></record> |
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| source | ScienceDirect Journals |
| subjects | Animals Blood Glucose - metabolism Body Composition - drug effects Chitosan - chemistry Chitosan oligosaccharides Diabetes Diabetes Mellitus, Experimental - complications Dysbiosis - complications Dysbiosis - drug therapy Dysbiosis - metabolism Dysbiosis - microbiology Dyslipidemias - complications Enzyme Activation - drug effects Gastrointestinal Microbiome - drug effects Gut microbiota Intestinal integrity Lipogenesis Male Mice Mice, Inbred C57BL Oligosaccharides - chemistry Oligosaccharides - pharmacology Oligosaccharides - therapeutic use p38 Mitogen-Activated Protein Kinases - metabolism |
| title | Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice |
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