CRP genetic variants are associated with mortality and depressive symptoms in chronic heart failure patients

•CRP genetic risk variants are associated with higher mortality risk in heart failure.•CRP genetic risk variants are associated with higher CRP levels in heart failure.•CRP genetic risk variants are associated with increased depressive symptoms in heart failure. Objective: Heart failure (HF) is a co...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2018-07, Vol.71, p.133-141
Main Authors: Kittel-Schneider, S., Kaspar, M., Berliner, D., Weber, H., Deckert, J., Ertl, G., Störk, S., Angermann, C., Reif, A.
Format: Article
Language:English
Subjects:
Aged
C-reactive protein
C-Reactive Protein - genetics
C-Reactive Protein - metabolism
C-Reactive Protein - physiology
Chronic Disease
Depression - blood
Depression - genetics
Depression - physiopathology
Depressive Disorder - blood
Depressive Disorder - genetics
Depressive Disorder - physiopathology
Female
Genetic Predisposition to Disease - genetics
Genetic Variation - genetics
Genotype
Heart failure
Heart Failure - genetics
Heart Failure - mortality
Heart Failure - psychology
Humans
Interleukin-6
Interleukin-6 - blood
Interleukin-6 - genetics
Interleukin-6 - physiology
Major depression
Male
Middle Aged
Polymorphism, Single Nucleotide - genetics
Risk Factors
Single nucleotide polymorphism
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Summary:•CRP genetic risk variants are associated with higher mortality risk in heart failure.•CRP genetic risk variants are associated with higher CRP levels in heart failure.•CRP genetic risk variants are associated with increased depressive symptoms in heart failure. Objective: Heart failure (HF) is a complex medical condition with a multitude of genetic and other factors being involved in the pathogenesis. Emerging evidence points to an involvement of inflammatory mechanisms at least in subgroups of patients. The same is true for depression and depressive symptoms, which have a high prevalence in HF patients and are risk factors for the development and outcomes of cardiovascular disease. Methods: In 936 patients of the Interdisciplinary Network Heart Failure (INH) program, CRP and IL-6 protein blood levels were measured and genetic variants (single nucleotide polymorphisms) of the CRP and IL6 gene analyzed regarding their influence on mortality. Results: Less common recessive genotypes of two single nucleotide polymorphisms in the CRP gene (rs1800947 and rs11265263) were associated with significantly higher mortality risk (p 
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2018.04.002