Structural-Functional Organization of the Eukaryotic Cell Nucleus and Transcription Regulation: Introduction to This Special Issue of Biochemistry (Moscow)

This issue of Biochemistry ( Moscow ) is devoted to the cell nucleus and mechanisms of transcription regulation. Over the years, biochemical processes in the cell nucleus have been studied in isolation, outside the context of their spatial organization. Now it is clear that segregation of functional...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2018-04, Vol.83 (4), p.299-301
Main Author: Razin, S. V.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Eukaryotes
Functional morphology
Gene expression
Gene regulation
Genetic aspects
Genomes
Life Sciences
Microbiology
Nuclei
Nuclei (cytology)
Observations
Stochastic processes
Structure-function relationships
Transcription
Transcription (Genetics)
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Summary:This issue of Biochemistry ( Moscow ) is devoted to the cell nucleus and mechanisms of transcription regulation. Over the years, biochemical processes in the cell nucleus have been studied in isolation, outside the context of their spatial organization. Now it is clear that segregation of functional processes within a compartmentalized cell nucleus is very important for the implementation of basic genetic processes. The functional compartmentalization of the cell nucleus is closely related to the spatial organization of the genome, which in turn plays a key role in the operation of epigenetic mechanisms. In this issue of Biochemistry ( Moscow ), we present a selection of review articles covering the functional architecture of the eukaryotic cell nucleus, the mechanisms of genome folding, the role of stochastic processes in establishing 3D architecture of the genome, and the impact of genome spatial organization on transcription regulation.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297918040016