Exopolysaccharide from Lactobacillus plantarum LRCC5310 offers protection against rotavirus-induced diarrhea and regulates inflammatory response

We aimed to determine the effects of Lactobacillus strains against rotaviral infections. Rotaviruses are the major causative agent of acute gastroenteritis in infants and children worldwide. However, to date, no specific antiviral drugs for the treatment of rotavirus infection have been developed. W...

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Bibliographic Details
Published in:Journal of dairy science 2018-07, Vol.101 (7), p.5702-5712
Main Authors: Kim, Kiyoung, Lee, Gyeonghweon, Thanh, Hien Dang, Kim, Jong-Hwa, Konkit, Maytiya, Yoon, Seokmin, Park, Miri, Yang, Siyoung, Park, Eunsup, Kim, Wonyong
Format: Article
Language:English
Subjects:
Animals
Antibiosis
Cattle
Cattle Diseases - prevention & control
Cattle Diseases - virology
Child
diarrhea
Diarrhea - prevention & control
Diarrhea - veterinary
Diarrhea - virology
exopolysaccharide
Gastroenteritis
Humans
Lactobacillus plantarum
Lactobacillus plantarum - physiology
Mice
rotavirus
Rotavirus - growth & development
Rotavirus - immunology
Rotavirus Infections - prevention & control
Rotavirus Infections - veterinary
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Summary:We aimed to determine the effects of Lactobacillus strains against rotaviral infections. Rotaviruses are the major causative agent of acute gastroenteritis in infants and children worldwide. However, to date, no specific antiviral drugs for the treatment of rotavirus infection have been developed. We identified 263 Lactobacillus strains from 35 samples of the traditional Korean fermented vegetable food kimchi. Among them, Lactobacillus plantarum LRCC5310, more specifically the exopolysaccharides produced by these cells, were shown to have an antiviral effect against human rotavirus Wa strain in vitro. In vivo, the oral administration of exopolysaccharides for 2 d before and 5 d after mouse infection with the murine rotavirus epidemic diarrhea of infant mice strain led to a decrease in the duration of diarrhea and viral shedding and prevented the destruction of enteric epithelium integrity in the infected mice. We demonstrated here that the exopolysaccharides extracted from L. plantarum LRCC5310 can be used for the effective control of rotavirus infection.
ISSN:0022-0302
1525-3198
DOI:10.3168/jds.2017-14151